Structure information

SMO

PROTEIN CLASS

Class F (Frizzled)

PDB CODE

4QIM

SPECIES

Homo sapiens

RESOLUTION

2.610

PREFERRED CHAIN

A

REFERENCE

10.1038/NCOMMS5355

PUBLICATION DATE

July 23, 2014

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ANTA XV I215 N-term hydrophobic
ANTA XV N219 N-term polar (hydrogen bond)
ANTA XV N219 N-term Van der Waals
ANTA XV L221 N-term Van der Waals
ANTA XV L221 N-term hydrophobic
ANTA XV M230 1.32x32 TM1 Van der Waals
ANTA XV M230 1.32x32 TM1 hydrophobic
ANTA XV W281 2.58x58 TM2 aromatic (edge-to-face)
ANTA XV W281 2.58x58 TM2 Van der Waals
ANTA XV D384 ECL2 Van der Waals
ANTA XV V386 ECL2 Van der Waals
ANTA XV V386 ECL2 hydrophobic
ANTA XV S387 ECL2 Van der Waals
ANTA XV F391 45.51x51 ECL2 Van der Waals
ANTA XV F391 45.51x51 ECL2 hydrophobic
ANTA XV Y394 ECL2 Van der Waals
ANTA XV Y394 ECL2 hydrophobic
ANTA XV K395 ECL2 polar (charge-assisted hydrogen bond)
ANTA XV R400 5.43x44 TM5 polar (charge-assisted hydrogen bond)
ANTA XV H470 6.51x51 TM6 Van der Waals
ANTA XV D473 6.54x54 TM6 polar (charge-assisted hydrogen bond)
ANTA XV Q477 6.58x58 TM6 Van der Waals
ANTA XV F484 6.65x65 TM6 hydrophobic
ANTA XV F484 6.65x65 TM6 Van der Waals
ANTA XV E518 7.38x38 TM7 polar (charge-assisted hydrogen bond)
ANTA XV N521 7.41x41 TM7 Van der Waals
ANTA XV L522 7.42x42 TM7 Van der Waals
ANTA XV L522 7.42x42 TM7 hydrophobic

Ligands

ANTA XV

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Residue Diagrams

L T C L G T V A G F A A I Y S H M D Q H 1 F Y V N A C F F V G S I G W L A Q F 2 V V F W V V G A M L A Y Y V I V F I I V 3 T S Y F H L L T W S L P F V L T V A I L 4 L F Y G G V I L V L G I P A L V F G A R Y 5 G I F G F L A F G F V L I T F S C H F Y 6 T S M A I G T G F M A F L N I K E V L L 7
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ICL1 W R N S N ICL1ECL1 M D G A R R E I V C R A D G T M R L G E P T S N E T ECL1ICL2 L G T T Y Q P L S G ICL2ECL2 Q V D G D S V S G I C F V G Y K ECL2ICL3 P G L L ICL3ECL3 G L P T K Q P I P D C E I K N R P ECL3N-term M A A A R P A R G P E L P L L G L L L L L L L G D P G R G A A S S G N A T G P G P R S A G G S A R R S A A V T G P P P P L S H C G R A A P C E P L R Y N V C L G S V L P Y G A T S T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D R F P E G C T N E V Q N I K F N S S G Q C E V P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F N-termC-term G Q S D D E P K R I K K S K M I A K A F S K R H E L L Q N P G Q E L S F S M H T V S H D G P V A G L A F D L N E P S A D V S S A W A Q H V T K M V A R R G A I L P Q D I S V T P V A T P V P P E E Q A N L W L V E A E I S P E L Q K R L G R K K K R R K R K K E V C P L A P P P E L H P P A P A P S T I P R L P Q L P R Q K C L V A A G A W G A G D S C R Q G A W T L V S N P F C P E P S P P Q D P F L P S A P A P V A W A H G R R Q G L G P I H S R T N L M D T E L M D A D S D F C-term T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D R Y P A V I L F Y V N A C F F V G S I G W L A Q F L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A K T S Y F H L L T W S L P F V L T V A I L A V A N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I S L L V E K I N L F A M F G T G I A M S T W V W T K A W R R L T T L L I T W C R
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Residue Table


GPCRdb(A)
GPCRdb(F)
SMO
TM1
1x35 1.32x32 M230
TM2
2x57 2.58x58 W281
ECL2
45x51 45.51x51 F391
TM5
5x40 5.43x44 R400
TM6
6x55 6.51x51 H470
6x58 6.54x54 D473
6x62 6.58x58 Q477
6x69 6.65x65 F484
TM7
7x35 7.38x38 E518
7x38 7.41x41 N521
7x39 7.42x42 L522