Structure information

P2Y1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4XNW

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE14287

PUBLICATION DATE

April 1, 2015

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MRS2500 C42 N-term polar (hydrogen bond with backbone)
MRS2500 C42 N-term Van der Waals
MRS2500 L44 N-term hydrophobic
MRS2500 L44 N-term Van der Waals
MRS2500 K46 N-term polar (charge-assisted hydrogen bond)
MRS2500 Y110 2.63x63 TM2 Van der Waals
MRS2500 Y110 2.63x63 TM2 polar (hydrogen bond)
MRS2500 R195 ECL2 polar (charge-assisted hydrogen bond)
MRS2500 T201 ECL2 polar (hydrogen bond)
MRS2500 T201 ECL2 Van der Waals
MRS2500 Y203 45.51x51 ECL2 Van der Waals
MRS2500 Y203 45.51x51 ECL2 hydrophobic
MRS2500 D204 45.52x52 ECL2 Van der Waals
MRS2500 D204 45.52x52 ECL2 polar (hydrogen bond with backbone)
MRS2500 T205 ECL2 polar (hydrogen bond with backbone)
MRS2500 T205 ECL2 polar (hydrogen bond)
MRS2500 N283 6.58x58 TM6 polar (hydrogen bond)
MRS2500 N283 6.58x58 TM6 polar (hydrogen bond)
MRS2500 N283 6.58x58 TM6 Van der Waals
MRS2500 A286 6.61x61 TM6 Van der Waals
MRS2500 R287 6.62x62 TM6 Van der Waals
MRS2500 Q291 ECL3 polar (hydrogen bond)
MRS2500 N299 7.28x27 TM7 Van der Waals
MRS2500 Y303 7.32x31 TM7 polar (hydrogen bond)
MRS2500 Y306 7.35x34 TM7 polar (hydrogen bond)
MRS2500 R310 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

MRS2500

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Residue Diagrams

S N G L F G I I F V L I Y V A P L Y Y F 1 F N L A L A D F L Y V L T L P A L I F Y 2 C T L F L I S G Y L N V H F I F R Q L K 3 A I C I S V L V W L I V V V A I S P I L 4 Y C G L I L V L P V C F M A V T T C M S Y 5 V I I V L T V F V A S Y I P F H V M K T M 6 I P D V C S N L S A L G R T V Q Y T A 7
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ICL1 M K P W ICL1ECL1 K T D W I F ECL1ICL2 P L K S L G R L ICL2ECL2 G T G V R K N K T I T C Y D T T S D E Y ECL2ICL3 D L D N S ICL3ECL3 F Q T P A ECL3N-term M T E V L W P A V P N G T D A A F L A G P G S S W G N S T V A S T A A V S S S F K C A L T K T G N-termC-term K A S R R S E A N L Q S K S E D M T L N I L P E F K Q N G D T S L C-term F Q F Y Y L P A V Y I L V F I I G F L G N S V A I W M F V F H S G I S V Y M F N L A L A D F L Y V L T L P A L I F Y Y F N G D A M C K L Q R F I F H V N L Y G S I L F L T C I S A H R Y S G V V Y K K K N A I C I S V L V W L I V V V A I S P I L F Y S L R S Y F I Y S M C T T V A M F C V P L V L I L G C Y G L I V R A L I Y K P L R R K S I Y L V I I V L T V F A V S Y I P F H V M K T M N L R A R L D M C A F N D R V Y A T Y Q V T R G L A S L N S C V D P I L Y F L A G D T L S R F R R R A T R
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Residue Table


GPCRdb(A)
GPCRdb(A)
P2Y1 receptor
TM2
2x63 2.63x63 Y110
ECL2
45x51 45.51x51 Y203
45x52 45.52x52 D204
TM6
6x58 6.58x58 N283
6x61 6.61x61 A286
6x62 6.62x62 R287
TM7
7x27 7.28x27 N299
7x31 7.32x31 Y303
7x34 7.35x34 Y306
7x38 7.39x38 R310