PDB
5GLH
Resolution
2.8 Å
Released
Sept. 7, 2016
Receptor
ETB
Class
A
Species
Homo sapiens
Ligand
Function
endothelin-1 (Human)
Agonist
Reference
10.1038/nature19319

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Ligand Amino Acid Generic Number Segment Interaction Type
endothelin-1 (Human) C90 N-term Van der Waals
endothelin-1 (Human) P93 N-term Van der Waals
endothelin-1 (Human) I94 N-term Van der Waals
endothelin-1 (Human) I96 N-term hydrophobic
endothelin-1 (Human) I157 2.60x59 TM2 hydrophobic
endothelin-1 (Human) N158 2.61x60 TM2 polar (hydrogen bond)
endothelin-1 (Human) K161 2.64x63 TM2 polar (hydrogen bond)
endothelin-1 (Human) E165 ECL1 hydrophobic
endothelin-1 (Human) D166 23.49x49 ECL1 Van der Waals
endothelin-1 (Human) V177 3.28x28 TM3 Van der Waals
endothelin-1 (Human) P178 3.29x29 TM3 hydrophobic
endothelin-1 (Human) Q181 3.32x32 TM3 Van der Waals
endothelin-1 (Human) K182 3.33x33 TM3 aromatic (pi-cation)
endothelin-1 (Human) K182 3.33x33 TM3 polar (charge-charge)
endothelin-1 (Human) V185 3.36x36 TM3 hydrophobic
endothelin-1 (Human) E236 4.60x61 TM4 Van der Waals
endothelin-1 (Human) F240 4.64x65 TM4 hydrophobic
endothelin-1 (Human) I243 ECL2 hydrophobic
endothelin-1 (Human) M245 ECL2 hydrophobic
endothelin-1 (Human) D246 ECL2 polar (hydrogen bond with backbone)
endothelin-1 (Human) Y247 ECL2 hydrophobic
endothelin-1 (Human) L252 ECL2 hydrophobic
endothelin-1 (Human) I254 ECL2 hydrophobic
endothelin-1 (Human) C255 45.50x50 ECL2 Van der Waals
endothelin-1 (Human) L256 45.51x51 ECL2 hydrophobic
endothelin-1 (Human) L257 45.52x52 ECL2 polar (hydrogen bond with backbone)
endothelin-1 (Human) H258 ECL2 Van der Waals
endothelin-1 (Human) P259 ECL2 hydrophobic
endothelin-1 (Human) K273 5.38x39 TM5 polar (charge-charge)
endothelin-1 (Human) K273 5.38x39 TM5 polar (hydrogen bond)
endothelin-1 (Human) K273 5.38x39 TM5 aromatic (pi-cation)
endothelin-1 (Human) L277 5.42x43 TM5 hydrophobic
endothelin-1 (Human) W336 6.48x48 TM6 hydrophobic
endothelin-1 (Human) L339 6.51x51 TM6 hydrophobic
endothelin-1 (Human) R343 6.55x55 TM6 polar (hydrogen bond)
endothelin-1 (Human) R343 6.55x55 TM6 polar (charge-charge)
endothelin-1 (Human) K346 6.58x58 TM6 polar (hydrogen bond)
endothelin-1 (Human) K346 6.58x58 TM6 hydrophobic
endothelin-1 (Human) Y350 6.62x62 TM6 polar (hydrogen bond)
endothelin-1 (Human) Q352 ECL3 Van der Waals
endothelin-1 (Human) R357 7.24x23 TM7 polar (charge-charge)
endothelin-1 (Human) C358 7.25x24 TM7 hydrophobic
endothelin-1 (Human) L361 7.28x27 TM7 hydrophobic
endothelin-1 (Human) L364 7.31x30 TM7 hydrophobic
endothelin-1 (Human) L365 7.32x31 TM7 hydrophobic
endothelin-1 (Human) D368 7.35x34 TM7 hydrophobic
endothelin-1 (Human) Y369 7.36x35 TM7 polar (hydrogen bond)
endothelin-1 (Human) Y369 7.36x35 TM7 hydrophobic
endothelin-1 (Human) I372 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K C M R ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
Helix box plot — Download: PNG | SVG S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7

GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x59 2.60x59 I157
2x60 2.61x60 N158
2x63 2.64x63 K161
ECL1
23x49 23.49x49 D166
TM3
3x28 3.28x28 V177
3x29 3.29x29 P178
3x32 3.32x32 Q181
3x33 3.33x33 K182
3x36 3.36x36 V185
TM4
4x61 4.60x61 E236
4x65 4.64x65 F240
ECL2
45x50 45.50x50 C255
45x51 45.51x51 L256
45x52 45.52x52 L257
TM5
5x39 5.38x39 K273
5x43 5.42x43 L277
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x55 6.55x55 R343
6x58 6.58x58 K346
6x62 6.62x62 Y350
TM7
7x23 7.24x23 R357
7x24 7.25x24 C358
7x27 7.28x27 L361
7x30 7.31x30 L364
7x31 7.32x31 L365
7x34 7.35x34 D368
7x35 7.36x35 Y369
7x38 7.39x38 I372