Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5GLH

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

PUBLICATION DATE

Sept. 7, 2016

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Et 1 I94 N-term hydrophobic
Et 1 I96 N-term hydrophobic
Et 1 N158 2.61x60 TM2 polar (hydrogen bond)
Et 1 K161 2.64x63 TM2 polar (charge-assisted hydrogen bond)
Et 1 E165 ECL1 polar (hydrogen bond with backbone)
Et 1 Q181 3.32x32 TM3 polar (hydrogen bond)
Et 1 K182 3.33x33 TM3 polar (charge-charge)
Et 1 E236 4.60x61 TM4 polar (charge-charge)
Et 1 I243 ECL2 hydrophobic
Et 1 M245 ECL2 hydrophobic
Et 1 D246 ECL2 polar (hydrogen bond with backbone)
Et 1 Y247 ECL2 aromatic (face-to-face)
Et 1 L252 ECL2 hydrophobic
Et 1 I254 ECL2 hydrophobic
Et 1 L256 45.51x51 ECL2 hydrophobic
Et 1 L257 45.52x52 ECL2 polar (hydrogen bond with backbone)
Et 1 L257 45.52x52 ECL2 polar (hydrogen bond with backbone)
Et 1 P259 ECL2 hydrophobic
Et 1 K273 5.38x39 TM5 polar (charge-charge)
Et 1 W336 6.48x48 TM6 hydrophobic
Et 1 L339 6.51x51 TM6 hydrophobic
Et 1 R343 6.55x55 TM6 polar (charge-charge)
Et 1 R343 6.55x55 TM6 polar (charge-charge)
Et 1 K346 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Et 1 Y350 6.62x62 TM6 polar (charge-assisted hydrogen bond)
Et 1 Y350 6.62x62 TM6 polar (charge-assisted hydrogen bond)
Et 1 Q352 ECL3 polar (hydrogen bond)
Et 1 R357 7.24x23 TM7 polar (charge-charge)
Et 1 L361 7.28x27 TM7 hydrophobic
Et 1 L365 7.32x31 TM7 hydrophobic
Et 1 D368 7.35x34 TM7 polar (charge-charge)
Et 1 D368 7.35x34 TM7 polar (charge-charge)
Et 1 Y369 7.36x35 TM7 polar (hydrogen bond)
Et 1 I372 7.39x38 TM7 hydrophobic

Ligands

Et 1

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x60 2.61x60 N158
2x63 2.64x63 K161
TM3
3x32 3.32x32 Q181
3x33 3.33x33 K182
TM4
4x61 4.60x61 E236
ECL2
45x51 45.51x51 L256
45x52 45.52x52 L257
TM5
5x39 5.38x39 K273
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x55 6.55x55 R343
6x58 6.58x58 K346
6x62 6.62x62 Y350
TM7
7x23 7.24x23 R357
7x27 7.28x27 L361
7x31 7.32x31 L365
7x34 7.35x34 D368
7x35 7.36x35 Y369
7x38 7.39x38 I372