Structure information

5-HT1B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5V54

SPECIES

Homo sapiens

RESOLUTION

3.900

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Feb. 7, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL428892 D129 3.32x32 TM3 polar (charge-charge)
CHEMBL428892 I130 3.33x33 TM3 hydrophobic
CHEMBL428892 C133 3.36x36 TM3 hydrophobic
CHEMBL428892 I137 3.40x40 TM3 hydrophobic
CHEMBL428892 V201 45.52x52 ECL2 hydrophobic
CHEMBL428892 W327 6.48x48 TM6 aromatic (face-to-edge)
CHEMBL428892 F330 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL428892 F331 6.52x52 TM6 aromatic (edge-to-face)
CHEMBL428892 Y359 7.43x42 TM7 polar (charge-assisted hydrogen bond)

Ligands

CHEMBL428892

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Residue Diagrams

A N S L T T A L T I L A L L M V L L V K 1 A S L A V T D L L V S L I V M P I S T M Y 2 V C L H L I S A T C C T I D S S L W F D 3 A A V M I A L V W V F S I S I S L P P F 4 Y L A I L L L T P F Y F A G V T S Y V T Y 5 G I I L G A F I V C W L P F F I I S L V 6 I P N I L S N L Y G L W T F F D F I A 7
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ICL1 R K L H ICL1ECL1 R W T L ECL1ICL2 A V E Y S A K R ICL2ECL2 R Q A K A E E E V S E C V V N T D ECL2ICL3 N R T G K R L T R A Q L I T D S P G S T S S V T S I N S R V P D V P S E S G S P V Y V N Q V K V R V S D A L L E K K ICL3ECL3 K D A C W F ECL3N-term M E E P G A Q C A P P P P A G S E T W V P Q A N L S S A P S Q N C S A K D Y I Y Q D S I N-termC-term R F K C T S C-term S L P W K V L L V M L L A L I T L A T T L S N A F V I A T V Y R T T P A N Y L I A S L A V T D L L V S I L V M P I S T M Y T V T G G Q V V C D F W L S S D I T C C T A S I L H L C V I A L D R Y W A I T D T P K R A A V M I A L V W V F S I S I S L P P F F W H I L Y T V Y S T V G A F Y F P T L L L I A L Y G R I Y V E A R S R I L K Q T P K L M A A R E R K A T K T L G I I L G A F I V C W L P F F I I S L V M P I C H L A I F D F F T W L G Y L N S L I N P I I Y T M S N E D F H K F K Q A L I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1B receptor
TM3
3x32 3.32x32 D129
3x33 3.33x33 I130
3x36 3.36x36 C133
3x40 3.40x40 I137
ECL2
45x52 45.52x52 V201
TM6
6x48 6.48x48 W327
6x51 6.51x51 F330
6x52 6.52x52 F331
TM7
7x42 7.43x42 Y359