Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5XR8

SPECIES

Homo sapiens

RESOLUTION

2.950

PREFERRED CHAIN

A

PUBLICATION DATE

July 12, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AM841 F170 2.57x57 TM2 hydrophobic
AM841 F174 2.61x61 TM2 hydrophobic
AM841 F177 2.64x64 TM2 hydrophobic
AM841 F189 3.25x25 TM3 hydrophobic
AM841 L193 3.29x29 TM3 hydrophobic
AM841 V196 3.32x32 TM3 hydrophobic
AM841 F200 3.36x36 TM3 hydrophobic
AM841 I267 ECL2 polar (hydrogen bond with backbone)
AM841 I267 ECL2 Van der Waals
AM841 F268 ECL2 Van der Waals
AM841 F268 ECL2 hydrophobic
AM841 I271 ECL2 Van der Waals
AM841 Y275 5.39x39 TM5 Van der Waals
AM841 L276 5.40x40 TM5 hydrophobic
AM841 L276 5.40x40 TM5 Van der Waals
AM841 W279 5.43x43 TM5 hydrophobic
AM841 W279 5.43x43 TM5 Van der Waals
AM841 L481 6.51x51 TM6 hydrophobic
AM841 L481 6.51x51 TM6 Van der Waals
AM841 M485 6.55x55 TM6 Van der Waals
AM841 F501 7.35x34 TM7 hydrophobic
AM841 F501 7.35x34 TM7 Van der Waals
AM841 S505 7.39x38 TM7 polar (hydrogen bond)
AM841 S505 7.39x38 TM7 Van der Waals
AM841 C508 7.42x41 TM7 Van der Waals

Ligands

AM841

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Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x61 2.61x61 F174
2x64 2.64x64 F177
TM3
3x25 3.25x25 F189
3x29 3.29x29 L193
3x32 3.32x32 V196
3x36 3.36x36 F200
TM5
5x39 5.39x39 Y275
5x40 5.40x40 L276
5x43 5.43x43 W279
TM6
6x51 6.51x51 L359
6x55 6.55x55 M363
TM7
7x34 7.35x34 F379
7x38 7.39x38 S383
7x41 7.42x41 C386