Structure information

D2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6CM4

SPECIES

Homo sapiens

RESOLUTION

2.870

PREFERRED CHAIN

A

PUBLICATION DATE

March 14, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Risperidone W100 23.50x50 ECL1 hydrophobic
Risperidone D114 3.32x32 TM3 polar (charge-charge)
Risperidone C118 3.36x36 TM3 polar (hydrogen bond with backbone)
Risperidone W386 6.48x48 TM6 aromatic (face-to-edge)
Risperidone F389 6.51x51 TM6 hydrophobic
Risperidone F390 6.52x52 TM6 aromatic (edge-to-face)
Risperidone Y408 7.35x34 TM7 hydrophobic
Risperidone Y416 7.43x42 TM7 polar (charge-assisted hydrogen bond)

Ligands

Risperidone

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Residue Diagrams

V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7
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ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
D2 receptor
ECL1
23x50 23.50x50 W100
TM3
3x32 3.32x32 D114
3x36 3.36x36 C118
TM6
6x48 6.48x48 W386
6x51 6.51x51 F389
6x52 6.52x52 F390
TM7
7x34 7.35x34 Y408
7x42 7.43x42 Y416