Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6LRY

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1016/J.BBRC.2019.12.091

PUBLICATION DATE

Feb. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
sarafotoxin S6b P87 N-term hydrophobic
sarafotoxin S6b I94 N-term hydrophobic
sarafotoxin S6b I157 2.60x59 TM2 hydrophobic
sarafotoxin S6b N158 2.61x60 TM2 polar (hydrogen bond)
sarafotoxin S6b K161 2.64x63 TM2 polar (charge-assisted hydrogen bond)
sarafotoxin S6b E165 ECL1 polar (charge-assisted hydrogen bond)
sarafotoxin S6b E165 ECL1 polar (hydrogen bond with backbone)
sarafotoxin S6b D166 23.49x49 ECL1 Van der Waals
sarafotoxin S6b V177 3.28x28 TM3 Van der Waals
sarafotoxin S6b V177 3.28x28 TM3 hydrophobic
sarafotoxin S6b P178 3.29x29 TM3 hydrophobic
sarafotoxin S6b Q181 3.32x32 TM3 Van der Waals
sarafotoxin S6b Q181 3.32x32 TM3 polar (hydrogen bond)
sarafotoxin S6b K182 3.33x33 TM3 polar (charge-assisted hydrogen bond)
sarafotoxin S6b I243 ECL2 hydrophobic
sarafotoxin S6b I243 ECL2 Van der Waals
sarafotoxin S6b M245 ECL2 hydrophobic
sarafotoxin S6b M245 ECL2 Van der Waals
sarafotoxin S6b D246 ECL2 polar (hydrogen bond with backbone)
sarafotoxin S6b D246 ECL2 Van der Waals
sarafotoxin S6b Y247 ECL2 Van der Waals
sarafotoxin S6b Y247 ECL2 polar (hydrogen bond)
sarafotoxin S6b K248 ECL2 polar (charge-assisted hydrogen bond)
sarafotoxin S6b L252 ECL2 hydrophobic
sarafotoxin S6b L252 ECL2 Van der Waals
sarafotoxin S6b R253 ECL2 Van der Waals
sarafotoxin S6b I254 ECL2 hydrophobic
sarafotoxin S6b I254 ECL2 Van der Waals
sarafotoxin S6b L256 45.51x51 ECL2 Van der Waals
sarafotoxin S6b L256 45.51x51 ECL2 hydrophobic
sarafotoxin S6b L257 45.52x52 ECL2 polar (hydrogen bond with backbone)
sarafotoxin S6b L257 45.52x52 ECL2 Van der Waals
sarafotoxin S6b P259 ECL2 Van der Waals
sarafotoxin S6b P259 ECL2 hydrophobic
sarafotoxin S6b K273 5.38x39 TM5 polar (charge-assisted hydrogen bond)
sarafotoxin S6b L277 5.42x43 TM5 hydrophobic
sarafotoxin S6b L277 5.42x43 TM5 Van der Waals
sarafotoxin S6b W336 6.48x48 TM6 hydrophobic
sarafotoxin S6b W336 6.48x48 TM6 Van der Waals
sarafotoxin S6b L339 6.51x51 TM6 hydrophobic
sarafotoxin S6b L339 6.51x51 TM6 Van der Waals
sarafotoxin S6b R343 6.55x55 TM6 polar (charge-assisted hydrogen bond)
sarafotoxin S6b K346 6.58x58 TM6 polar (charge-assisted hydrogen bond)
sarafotoxin S6b Y350 6.62x62 TM6 Van der Waals
sarafotoxin S6b Y350 6.62x62 TM6 polar (hydrogen bond)
sarafotoxin S6b Q352 ECL3 Van der Waals
sarafotoxin S6b R357 7.24x23 TM7 polar (charge-assisted hydrogen bond)
sarafotoxin S6b C358 7.25x24 TM7 Van der Waals
sarafotoxin S6b C358 7.25x24 TM7 polar (hydrogen bond)
sarafotoxin S6b L361 7.28x27 TM7 hydrophobic
sarafotoxin S6b L361 7.28x27 TM7 Van der Waals
sarafotoxin S6b L364 7.31x30 TM7 hydrophobic
sarafotoxin S6b L364 7.31x30 TM7 Van der Waals
sarafotoxin S6b L365 7.32x31 TM7 hydrophobic
sarafotoxin S6b L365 7.32x31 TM7 Van der Waals
sarafotoxin S6b D368 7.35x34 TM7 polar (charge-assisted hydrogen bond)
sarafotoxin S6b Y369 7.36x35 TM7 polar (hydrogen bond)
sarafotoxin S6b Y369 7.36x35 TM7 Van der Waals
sarafotoxin S6b I372 7.39x38 TM7 hydrophobic
sarafotoxin S6b I372 7.39x38 TM7 Van der Waals

Ligands

sarafotoxin S6b

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x59 2.60x59 I157
2x60 2.61x60 N158
2x63 2.64x63 K161
ECL1
23x49 23.49x49 D166
TM3
3x28 3.28x28 V177
3x29 3.29x29 P178
3x32 3.32x32 Q181
3x33 3.33x33 K182
ECL2
45x51 45.51x51 L256
45x52 45.52x52 L257
TM5
5x39 5.38x39 K273
5x43 5.42x43 L277
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x55 6.55x55 R343
6x58 6.58x58 K346
6x62 6.62x62 Y350
TM7
7x23 7.24x23 R357
7x24 7.25x24 C358
7x27 7.28x27 L361
7x30 7.31x30 L364
7x31 7.32x31 L365
7x34 7.35x34 D368
7x35 7.36x35 Y369
7x38 7.39x38 I372