Structure information

PAC1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6M1I

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

A

PUBLICATION DATE

March 11, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PACAP D23 N-term polar (hydrogen bond with backbone)
PACAP I61 N-term hydrophobic
PACAP L80 N-term hydrophobic
PACAP I83 N-term hydrophobic
PACAP F84 N-term hydrophobic
PACAP D145 N-term polar (charge-assisted hydrogen bond)
PACAP D147 1.33x33 TM1 polar (hydrogen bond with backbone)
PACAP Y150 1.36x36 TM1 polar (hydrogen bond)
PACAP Y150 1.36x36 TM1 aromatic (face-to-face)
PACAP Y150 1.36x36 TM1 polar (hydrogen bond)
PACAP V153 1.39x39 TM1 hydrophobic
PACAP Y157 1.43x43 TM1 aromatic (edge-to-face)
PACAP Y161 1.47x47 TM1 polar (charge-assisted hydrogen bond)
PACAP R199 2.60x60 TM2 polar (charge-charge)
PACAP L210 2.71x71 TM2 polar (hydrogen bond with backbone)
PACAP D215 ECL1 polar (charge-assisted hydrogen bond)
PACAP D215 ECL1 polar (charge-assisted hydrogen bond)
PACAP C219 ECL1 polar (hydrogen bond with backbone)
PACAP F233 3.36x36 TM3 hydrophobic
PACAP M299 ECL2 hydrophobic
PACAP D301 ECL2 polar (charge-charge)
PACAP D301 ECL2 polar (charge-charge)
PACAP W306 5.36x37 TM5 hydrophobic
PACAP L382 7.39x38 TM7 hydrophobic
PACAP L386 7.43x42 TM7 hydrophobic

Ligands

PACAP

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Residue Diagrams

T L T V L S T S Y G V T Y L A K V S L Y 1 M N L F V S F M L R A I S V F I K D W I 2 I F L W F Y N S V V C Y H F F V M V A K 3 Y F Y W Y T I G I W G T P T V C V T V W A 4 F L V F N V M I S G V V P G K I V W W L A 5 L L L I P L F G I H Y T V F A F S 6 V A V V F G Q F S G L G L E F V L R E 7
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ICL1 R K L H ICL1ECL1 Y A E Q D S N H C F I S ECL1ICL2 T F F P E R ICL2ECL2 D T G C W D M N D ECL2ICL3 Q S P D M G G ICL3ECL3 P E N V S ECL3N-term M A G V V H V S L A A L L L L P M A P A M H S D C I F K K E Q A M C L E K I Q R A N E L M G F N D S S P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q V W E T E T I G E S D F G D S N S L D L S D M G V V S R N C T E D G W S E P F P H Y F D A C G F D E N-termC-term H R H P S L A S S G V N G G T Q L S I L S K S S S Q I R M S G L P A D N L A T C-term Y E S E T G D Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F C T R N F I H M N L F V S F M L R A I S V F I K D W I L T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L N E S S I Y L R L A R S T L L L I P L F G I H Y T V F A F S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E I K R W K V A V D V Q A E K W R S N R Y F F K
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Residue Table


GPCRdb(A)
GPCRdb(B)
PAC1 receptor
TM1
1x29 1.33x33 D147
1x32 1.36x36 Y150
1x35 1.39x39 V153
1x39 1.43x43 Y157
1x43 1.47x47 Y161
TM2
2x53 2.60x60 R199
2x64 2.71x71 L210
TM3
3x32 3.36x36 F233
TM5
5x41 5.36x37 W306
TM7
7x34 7.39x38 L382
7x38 7.43x42 L386