Structure information

PAC1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6M1I

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

A

PUBLICATION DATE

March 11, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL524658 D23 N-term polar (hydrogen bond with backbone)
CHEMBL524658 I61 N-term hydrophobic
CHEMBL524658 L80 N-term hydrophobic
CHEMBL524658 I83 N-term hydrophobic
CHEMBL524658 F84 N-term hydrophobic
CHEMBL524658 D145 N-term polar (charge-assisted hydrogen bond)
CHEMBL524658 D147 1.33x33 TM1 polar (hydrogen bond with backbone)
CHEMBL524658 Y150 1.36x36 TM1 polar (hydrogen bond)
CHEMBL524658 Y150 1.36x36 TM1 aromatic (face-to-face)
CHEMBL524658 Y150 1.36x36 TM1 polar (hydrogen bond)
CHEMBL524658 V153 1.39x39 TM1 hydrophobic
CHEMBL524658 Y157 1.43x43 TM1 aromatic (edge-to-face)
CHEMBL524658 Y161 1.47x47 TM1 polar (charge-assisted hydrogen bond)
CHEMBL524658 R199 2.60x60 TM2 polar (charge-charge)
CHEMBL524658 L210 2.71x71 TM2 polar (hydrogen bond with backbone)
CHEMBL524658 D215 ECL1 polar (charge-assisted hydrogen bond)
CHEMBL524658 D215 ECL1 polar (charge-assisted hydrogen bond)
CHEMBL524658 C219 ECL1 polar (hydrogen bond with backbone)
CHEMBL524658 F233 3.36x36 TM3 hydrophobic
CHEMBL524658 M299 ECL2 hydrophobic
CHEMBL524658 D301 ECL2 polar (charge-charge)
CHEMBL524658 D301 ECL2 polar (charge-charge)
CHEMBL524658 W306 5.36x37 TM5 hydrophobic
CHEMBL524658 L382 7.39x38 TM7 hydrophobic
CHEMBL524658 L386 7.43x42 TM7 hydrophobic

Ligands

CHEMBL524658

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Residue Diagrams

T L T V L S T S Y G V T Y L A K V S L Y 1 M N L F V S F M L R A I S V F I K D W I 2 I F L W F Y N S V V C Y H F F V M V A K 3 Y F Y W Y T I G I W G T P T V C V T V W A 4 F L V F N V M I S G V V P G K I V W W L A 5 L L L I P L F G I H Y T V F A F S 6 V A V V F G Q F S G L G L E F V L R E 7
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ICL1 R K L H ICL1ECL1 Y A E Q D S N H C F I S ECL1ICL2 T F F P E R ICL2ECL2 D T G C W D M N D ECL2ICL3 Q S P D M G G ICL3ECL3 P E N V S ECL3N-term M A G V V H V S L A A L L L L P M A P A M H S D C I F K K E Q A M C L E K I Q R A N E L M G F N D S S P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q V W E T E T I G E S D F G D S N S L D L S D M G V V S R N C T E D G W S E P F P H Y F D A C G F D E N-termC-term H R H P S L A S S G V N G G T Q L S I L S K S S S Q I R M S G L P A D N L A T C-term Y E S E T G D Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F C T R N F I H M N L F V S F M L R A I S V F I K D W I L T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L N E S S I Y L R L A R S T L L L I P L F G I H Y T V F A F S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E I K R W K V A V D V Q A E K W R S N R Y F F K
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Residue Table


GPCRdb(A)
GPCRdb(B)
PAC1 receptor
TM1
1x29 1.33x33 D147
1x32 1.36x36 Y150
1x35 1.39x39 V153
1x39 1.43x43 Y157
1x43 1.47x47 Y161
TM2
2x53 2.60x60 R199
2x64 2.71x71 L210
TM3
3x32 3.36x36 F233
TM5
5x41 5.36x37 W306
TM7
7x34 7.39x38 L382
7x38 7.43x42 L386