Structure information

β2-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6N48

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

A

PUBLICATION DATE

June 26, 2019

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
BI-167107 D1113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
BI-167107 D1113 3.32x32 TM3 polar (charge-charge)
BI-167107 V1114 3.33x33 TM3 hydrophobic
2-[[(3R)-4-(4-Tert-butylphenyl)-3-[[2-(4-methoxyphenyl)sulfanyl-5-[methyl(propan-2-yl)sulfamoyl]benzoyl]amino]butanoyl]amino]acetic acid F1133 3.52x52 TM3 aromatic (face-to-edge)
2-[[(3R)-4-(4-Tert-butylphenyl)-3-[[2-(4-methoxyphenyl)sulfanyl-5-[methyl(propan-2-yl)sulfamoyl]benzoyl]amino]butanoyl]amino]acetic acid Y1141 34.53x53 ICL2 hydrophobic
2-[[(3R)-4-(4-Tert-butylphenyl)-3-[[2-(4-methoxyphenyl)sulfanyl-5-[methyl(propan-2-yl)sulfamoyl]benzoyl]amino]butanoyl]amino]acetic acid L1144 34.56x56 ICL2 hydrophobic
2-[[(3R)-4-(4-Tert-butylphenyl)-3-[[2-(4-methoxyphenyl)sulfanyl-5-[methyl(propan-2-yl)sulfamoyl]benzoyl]amino]butanoyl]amino]acetic acid K1149 4.41x41 TM4 polar (charge-assisted hydrogen bond)
2-[[(3R)-4-(4-Tert-butylphenyl)-3-[[2-(4-methoxyphenyl)sulfanyl-5-[methyl(propan-2-yl)sulfamoyl]benzoyl]amino]butanoyl]amino]acetic acid I1153 4.45x45 TM4 hydrophobic
BI-167107 F1193 45.52x52 ECL2 hydrophobic
BI-167107 S1203 5.42x43 TM5 polar (hydrogen bond)
BI-167107 S1203 5.42x43 TM5 polar (hydrogen bond)
BI-167107 S1207 5.46x461 TM5 polar (hydrogen bond)
BI-167107 F1289 6.51x51 TM6 aromatic (edge-to-face)
BI-167107 F1290 6.52x52 TM6 aromatic (edge-to-face)
BI-167107 N1293 6.55x55 TM6 polar (hydrogen bond)
BI-167107 N1312 7.39x38 TM7 polar (hydrogen bond)
BI-167107 N1312 7.39x38 TM7 polar (hydrogen bond)
BI-167107 N1312 7.39x38 TM7 polar (charge-assisted hydrogen bond)
BI-167107 Y1316 7.43x42 TM7 polar (charge-assisted hydrogen bond)

Ligands

BI-167107

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


2-[[(3R)-4-(4-Tert-butylphenyl)-3-[[2-(4-methoxyphenyl)sulfanyl-5-[methyl(propan-2-yl)sulfamoyl]benzoyl]amino]butanoyl]amino]acetic acid

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7
Download: PNG | SVG
ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x32 3.32x32 D113
3x33 3.33x33 V114
3x52 3.52x52 F133
ICL2
34x53 34.53x53 Y141
34x56 34.56x56 L144
TM4
4x41 4.41x41 K149
4x45 4.45x45 I153
ECL2
45x52 45.52x52 F193
TM5
5x43 5.42x43 S203
5x461 5.46x461 S207
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
6x55 6.55x55 N293
TM7
7x38 7.39x38 N312
7x42 7.43x42 Y316