Structure information

PAC1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6P9Y

SPECIES

Homo sapiens

RESOLUTION

3.010

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2020.01.012

PUBLICATION DATE

Feb. 5, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
[Ac-His<sup>1</sup>]PACAP-27 Y148 N-term aromatic (face-to-face)
[Ac-His<sup>1</sup>]PACAP-27 Y150 1.36x36 TM1 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 V153 1.39x39 TM1 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 Y157 1.43x43 TM1 aromatic (edge-to-face)
[Ac-His<sup>1</sup>]PACAP-27 Y161 1.47x47 TM1 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 Y161 1.47x47 TM1 polar (hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 R199 2.60x60 TM2 polar (charge-assisted hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 K206 2.67x67 TM2 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 Y211 2.72x72 TM2 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 Y211 2.72x72 TM2 polar (hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 F233 3.36x36 TM3 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 F233 3.36x36 TM3 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 H234 3.37x37 TM3 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 H234 3.37x37 TM3 aromatic (face-to-edge)
[Ac-His<sup>1</sup>]PACAP-27 V237 3.40x40 TM3 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 V237 3.40x40 TM3 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 Y241 3.44x44 TM3 polar (hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 Y241 3.44x44 TM3 polar (hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 D298 45.52x52 ECL2 polar (hydrogen bond with backbone)
[Ac-His<sup>1</sup>]PACAP-27 D298 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 M299 ECL2 polar (hydrogen bond with backbone)
[Ac-His<sup>1</sup>]PACAP-27 M299 ECL2 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 D301 ECL2 polar (charge-assisted hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 W306 5.36x37 TM5 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 W306 5.36x37 TM5 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 V313 5.43x43 TM5 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 V313 5.43x43 TM5 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 E374 ECL3 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 K378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
[Ac-His<sup>1</sup>]PACAP-27 R381 7.38x37 TM7 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 L382 7.39x38 TM7 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 L382 7.39x38 TM7 hydrophobic
[Ac-His<sup>1</sup>]PACAP-27 E385 7.42x41 TM7 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 L386 7.43x42 TM7 Van der Waals
[Ac-His<sup>1</sup>]PACAP-27 L386 7.43x42 TM7 hydrophobic

Ligands

[Ac-His<sup>1</sup>]PACAP-27

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Residue Diagrams

T L T V L S T S Y G V T Y L A K V S L Y 1 M N L F V S F M L R A I S V F I K D W I 2 I F L W F Y N S V V C Y H F F V M V A K 3 Y F Y W Y T I G I W G T P T V C V T V W A 4 F L V F N V M I S G V V P G K I V W W L A 5 L L L I P L F G I H Y T V F A F S 6 V A V V F G Q F S G L G L E F V L R E 7
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ICL1 R K L H ICL1ECL1 Y A E Q D S N H C F I S ECL1ICL2 T F F P E R ICL2ECL2 D T G C W D M N D ECL2ICL3 Q S P D M G G ICL3ECL3 P E N V S ECL3N-term M A G V V H V S L A A L L L L P M A P A M H S D C I F K K E Q A M C L E K I Q R A N E L M G F N D S S P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q V W E T E T I G E S D F G D S N S L D L S D M G V V S R N C T E D G W S E P F P H Y F D A C G F D E N-termC-term H R H P S L A S S G V N G G T Q L S I L S K S S S Q I R M S G L P A D N L A T C-term Y E S E T G D Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F C T R N F I H M N L F V S F M L R A I S V F I K D W I L T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L N E S S I Y L R L A R S T L L L I P L F G I H Y T V F A F S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E I K R W K V A V D V Q A E K W R S N R Y F F K
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Residue Table


GPCRdb(A)
GPCRdb(B)
PAC1 receptor
TM1
1x32 1.36x36 Y150
1x35 1.39x39 V153
1x39 1.43x43 Y157
1x43 1.47x47 Y161
TM2
2x53 2.60x60 R199
2x60 2.67x67 K206
TM3
3x32 3.36x36 F233
3x33 3.37x37 H234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 D298
TM5
5x41 5.36x37 W306
5x47 5.43x43 V313
TM7
7x30 7.35x34 K378
7x33 7.38x37 R381
7x34 7.39x38 L382
7x37 7.42x41 E385
7x38 7.43x42 L386