Structure information

PAC1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6P9Y

SPECIES

Homo sapiens

RESOLUTION

3.010

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Feb. 5, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL524658 Y148 N-term aromatic (face-to-face)
CHEMBL524658 Y150 1.36x36 TM1 hydrophobic
CHEMBL524658 Y157 1.43x43 TM1 aromatic (edge-to-face)
CHEMBL524658 Y161 1.47x47 TM1 polar (charge-assisted hydrogen bond)
CHEMBL524658 Y161 1.47x47 TM1 polar (charge-assisted hydrogen bond)
CHEMBL524658 R199 2.60x60 TM2 polar (charge-charge)
CHEMBL524658 R199 2.60x60 TM2 polar (charge-assisted hydrogen bond)
CHEMBL524658 Y211 2.72x72 TM2 polar (hydrogen bond)
CHEMBL524658 F233 3.36x36 TM3 hydrophobic
CHEMBL524658 H234 3.37x37 TM3 aromatic (face-to-edge)
CHEMBL524658 V237 3.40x40 TM3 hydrophobic
CHEMBL524658 Y241 3.44x44 TM3 polar (hydrogen bond)
CHEMBL524658 Y241 3.44x44 TM3 polar (hydrogen bond)
CHEMBL524658 D298 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL524658 D298 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL524658 M299 ECL2 polar (hydrogen bond with backbone)
CHEMBL524658 M299 ECL2 polar (hydrogen bond with backbone)
CHEMBL524658 D301 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL524658 D301 ECL2 polar (charge-charge)
CHEMBL524658 W306 5.36x37 TM5 hydrophobic
CHEMBL524658 V313 5.43x43 TM5 hydrophobic
CHEMBL524658 K378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
CHEMBL524658 L382 7.39x38 TM7 hydrophobic
CHEMBL524658 L386 7.43x42 TM7 hydrophobic

Ligands

CHEMBL524658

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Residue Diagrams

T L T V L S T S Y G V T Y L A K V S L Y 1 M N L F V S F M L R A I S V F I K D W I 2 I F L W F Y N S V V C Y H F F V M V A K 3 Y F Y W Y T I G I W G T P T V C V T V W A 4 F L V F N V M I S G V V P G K I V W W L A 5 L L L I P L F G I H Y T V F A F S 6 V A V V F G Q F S G L G L E F V L R E 7
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ICL1 R K L H ICL1ECL1 Y A E Q D S N H C F I S ECL1ICL2 T F F P E R ICL2ECL2 D T G C W D M N D ECL2ICL3 Q S P D M G G ICL3ECL3 P E N V S ECL3N-term M A G V V H V S L A A L L L L P M A P A M H S D C I F K K E Q A M C L E K I Q R A N E L M G F N D S S P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q V W E T E T I G E S D F G D S N S L D L S D M G V V S R N C T E D G W S E P F P H Y F D A C G F D E N-termC-term H R H P S L A S S G V N G G T Q L S I L S K S S S Q I R M S G L P A D N L A T C-term Y E S E T G D Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F C T R N F I H M N L F V S F M L R A I S V F I K D W I L T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L N E S S I Y L R L A R S T L L L I P L F G I H Y T V F A F S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E I K R W K V A V D V Q A E K W R S N R Y F F K
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Residue Table


GPCRdb(A)
GPCRdb(B)
PAC1 receptor
TM1
1x32 1.36x36 Y150
1x39 1.43x43 Y157
1x43 1.47x47 Y161
TM2
2x53 2.60x60 R199
TM3
3x32 3.36x36 F233
3x33 3.37x37 H234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 D298
TM5
5x41 5.36x37 W306
5x47 5.43x43 V313
TM7
7x30 7.35x34 K378
7x34 7.39x38 L382
7x38 7.43x42 L386