Structure information

CysLT2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6RZ6

SPECIES

Homo sapiens

RESOLUTION

2.430

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-019-13348-2

PUBLICATION DATE

Dec. 11, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ONO-2570366 K37 1.31x31 TM1 polar (charge-assisted hydrogen bond)
ONO-2570366 F41 1.35x35 TM1 Van der Waals
ONO-2570366 Y119 3.33x33 TM3 polar (hydrogen bond)
ONO-2570366 Y119 3.33x33 TM3 polar (hydrogen bond)
ONO-2570366 Y123 3.37x37 TM3 Van der Waals
ONO-2570366 Y123 3.37x37 TM3 hydrophobic
ONO-2570366 Y127 3.41x41 TM3 Van der Waals
ONO-2570366 S169 4.56x56 TM4 Van der Waals
ONO-2570366 S170 4.57x57 TM4 Van der Waals
ONO-2570366 L188 45.51x51 ECL2 Van der Waals
ONO-2570366 L190 ECL2 Van der Waals
ONO-2570366 L190 ECL2 hydrophobic
ONO-2570366 L198 5.35x36 TM5 Van der Waals
ONO-2570366 L198 5.35x36 TM5 hydrophobic
ONO-2570366 M201 5.38x39 TM5 Van der Waals
ONO-2570366 M201 5.38x39 TM5 hydrophobic
ONO-2570366 N202 5.39x40 TM5 Van der Waals
ONO-2570366 I204 5.41x42 TM5 hydrophobic
ONO-2570366 I204 5.41x42 TM5 Van der Waals
ONO-2570366 A205 5.42x43 TM5 hydrophobic
ONO-2570366 A205 5.42x43 TM5 Van der Waals
ONO-2570366 V208 5.45x46 TM5 Van der Waals
ONO-2570366 V208 5.45x46 TM5 hydrophobic
ONO-2570366 G209 5.46x461 TM5 Van der Waals
ONO-2570366 R267 6.55x55 TM6 polar (charge-assisted hydrogen bond)
ONO-2570366 H270 6.58x58 TM6 Van der Waals
ONO-2570366 L271 6.59x59 TM6 hydrophobic
ONO-2570366 L271 6.59x59 TM6 Van der Waals
ONO-2570366 H284 7.32x31 TM7 polar (hydrogen bond)
ONO-2570366 H284 7.32x31 TM7 Van der Waals
ONO-2570366 L287 7.35x34 TM7 Van der Waals
ONO-2570366 L287 7.35x34 TM7 hydrophobic

Ligands

ONO-2570366

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Residue Diagrams

G N G L V G W F F I I L Y V I P F F E R 1 L N L A I S D L L F I S T L P F R A D Y 2 V T L F Y I S S Y M N V Y L S Y S M I R 3 A W I L C G I I W I L I M A S S I M L 4 Y C I S L T F F P L L C G V V L A I Y N M 5 I I I T L I I F L F C F L P Y H T L R T V 6 L P N F C A N A A A L A L T I V L A K 7
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ICL1 Y K K S ICL1ECL1 S N W I F ECL1ICL2 P F R L L H V T ICL2ECL2 G S E Q N G S V T S C L E L N L Y K ECL2ICL3 E V P E ICL3ECL3 K V G L C ECL3N-term M E R K F M S L Q P S I S V S E M E P N G T F S N N N S R N N-termC-term G H P Q K A K T K C V F P V S V W L R K E T R V C-term C T I E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H S I R S A W I L C G I I W I L I M A S S I M L L D S I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K V S G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N L K S F K D R A L R K
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Residue Table


GPCRdb(A)
GPCRdb(A)
CysLT2 receptor
TM1
1x31 1.31x31 K37
1x35 1.35x35 F41
TM3
3x33 3.33x33 Y119
3x37 3.37x37 Y123
3x41 3.41x41 Y127
TM4
4x56 4.56x56 S169
4x57 4.57x57 S170
ECL2
45x51 45.51x51 L188
TM5
5x36 5.35x36 L198
5x39 5.38x39 M201
5x40 5.39x40 N202
5x42 5.41x42 I204
5x43 5.42x43 A205
5x46 5.45x46 V208
5x461 5.46x461 G209
TM6
6x55 6.55x55 R267
6x58 6.58x58 H270
6x59 6.59x59 L271
TM7
7x31 7.32x31 H284
7x34 7.35x34 L287