Structure information

OX1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6TP4

SPECIES

Homo sapiens

RESOLUTION

3.010

PREFERRED CHAIN

A

REFERENCE

10.1021/acs.jmedchem.9b01787

PUBLICATION DATE

Jan. 1, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ACT-462206 C99 2.57x56 TM2 polar (hydrogen bond with backbone)
ACT-462206 C99 2.57x56 TM2 Van der Waals
ACT-462206 A102 2.60x59 TM2 Van der Waals
ACT-462206 S103 2.61x60 TM2 Van der Waals
ACT-462206 S103 2.61x60 TM2 polar (hydrogen bond with backbone)
ACT-462206 V106 2.64x63 TM2 Van der Waals
ACT-462206 W112 23.50x50 ECL1 Van der Waals
ACT-462206 I122 3.28x28 TM3 hydrophobic
ACT-462206 I122 3.28x28 TM3 Van der Waals
ACT-462206 P123 3.29x29 TM3 polar (hydrogen bond with backbone)
ACT-462206 P123 3.29x29 TM3 Van der Waals
ACT-462206 Q126 3.32x32 TM3 Van der Waals
ACT-462206 A127 3.33x33 TM3 Van der Waals
ACT-462206 Q179 4.60x61 TM4 polar (hydrogen bond)
ACT-462206 C202 45.50x50 ECL2 Van der Waals
ACT-462206 E204 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
ACT-462206 F219 5.42x43 TM5 hydrophobic
ACT-462206 F219 5.42x43 TM5 Van der Waals
ACT-462206 T223 5.46x461 TM5 polar (hydrogen bond)
ACT-462206 Y224 5.47x47 TM5 Van der Waals
ACT-462206 I314 6.51x51 TM6 Van der Waals
ACT-462206 I314 6.51x51 TM6 hydrophobic
ACT-462206 S315 6.52x52 TM6 polar (hydrogen bond)
ACT-462206 S315 6.52x52 TM6 polar (hydrogen bond)
ACT-462206 N318 6.55x55 TM6 polar (hydrogen bond)
ACT-462206 N318 6.55x55 TM6 polar (hydrogen bond)
ACT-462206 Y348 7.43x42 TM7 polar (hydrogen bond)

Ligands

ACT-462206

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Residue Diagrams

T N G V L A V V F V A V Y A A I L V W E 1 V N L S L A D V L V T I A C L P A S L L V 2 F S L T L V A V S V S V A Q L Y P I V K 3 A R G S I L G I W A V S L A I M V P Q 4 Y A M A M L G L P A L Y T V I F F C S H Y 5 M V V L L V F A L C Y L P I S V L N V L 6 I P N A A S N A Y V L W H S F T F C A 7
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ICL1 H H M R ICL1ECL1 S W L F ECL1ICL2 P L L F K S ICL2ECL2 E C S S V L P E L A N R T R L F S V C D E R W A D D ECL2ICL3 G T T S A L V R N W K R P S D Q L G D L E Q G L S G E P Q P R A R A ICL3ECL3 G M F R Q A S ECL3N-term M E P S A T P G A Q M G V P P G S R E P S P V P P D Y E D E F L R Y L W R D Y L Y P K Q Y N-termC-term G L G P C G S L K A P S P R S S A S H K S L S L Q S R C S I S K I S E H V V L T S V T T V L P C-term E W V L I A A Y V A V F V V A L V G N T L V C L A V W R N T V T N Y F I V N L S L A D V L V T A I C L P A S L L V D I T E G H A L C K V I P Y L Q A V S V S V A V L T L S F I A L D R W Y A I C H T A R R A R G S I L G I W A V S L A I M V P Q A A V M L Y P K I Y H S C F F I V T Y L A P L G L M A M A Y F Q I F R K L W G R Q I P F L A E V K Q M R A R R K T A K M L M V V L L V F A L C Y L P I S V L N V L K R V F D R E A V Y A C F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C L P F R E Q A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX1 receptor
TM2
2x56 2.57x56 C99
2x59 2.60x59 A102
2x60 2.61x60 S103
2x63 2.64x63 V106
ECL1
23x50 23.50x50 W112
TM3
3x28 3.28x28 I122
3x29 3.29x29 P123
3x32 3.32x32 Q126
3x33 3.33x33 A127
TM4
4x61 4.60x61 Q179
ECL2
45x50 45.50x50 C202
45x52 45.52x52 E204
TM5
5x43 5.42x43 F219
5x461 5.46x461 T223
5x47 5.47x47 Y224
TM6
6x51 6.51x51 I314
6x52 6.52x52 S315
6x55 6.55x55 N318
TM7
7x42 7.43x42 Y348