Structure information

OX2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6TPG

SPECIES

Homo sapiens

RESOLUTION

2.740

PREFERRED CHAIN

A

REFERENCE

10.1021/acs.jmedchem.9b01787

PUBLICATION DATE

Jan. 1, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
EMPA T111 2.61x60 TM2 polar (hydrogen bond)
EMPA V114 2.64x63 TM2 Van der Waals
EMPA W120 23.50x50 ECL1 Van der Waals
EMPA I130 3.28x28 TM3 Van der Waals
EMPA P131 3.29x29 TM3 Van der Waals
EMPA P131 3.29x29 TM3 hydrophobic
EMPA Q134 3.32x32 TM3 polar (hydrogen bond)
EMPA T135 3.33x33 TM3 Van der Waals
EMPA V138 3.36x36 TM3 Van der Waals
EMPA V138 3.36x36 TM3 hydrophobic
EMPA Q187 4.60x61 TM4 polar (hydrogen bond)
EMPA M191 4.64x65 TM4 Van der Waals
EMPA C210 45.50x50 ECL2 polar (hydrogen bond with backbone)
EMPA C210 45.50x50 ECL2 Van der Waals
EMPA E212 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
EMPA H224 5.39x40 TM5 Van der Waals
EMPA F227 5.42x43 TM5 Van der Waals
EMPA F227 5.42x43 TM5 aromatic (edge-to-face)
EMPA Y317 6.48x48 TM6 Van der Waals
EMPA I320 6.51x51 TM6 hydrophobic
EMPA I320 6.51x51 TM6 Van der Waals
EMPA S321 6.52x52 TM6 polar (hydrogen bond)
EMPA N324 6.55x55 TM6 polar (hydrogen bond)
EMPA H350 7.39x38 TM7 polar (hydrogen bond with backbone)
EMPA H350 7.39x38 TM7 polar (hydrogen bond)
EMPA V353 7.42x41 TM7 hydrophobic
EMPA V353 7.42x41 TM7 Van der Waals
EMPA Y354 7.43x42 TM7 polar (hydrogen bond)

Ligands

EMPA

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Residue Diagrams

V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7
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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX2 receptor
TM2
2x60 2.61x60 T111
2x63 2.64x63 V114
ECL1
23x50 23.50x50 W120
TM3
3x28 3.28x28 I130
3x29 3.29x29 P131
3x32 3.32x32 Q134
3x33 3.33x33 T135
3x36 3.36x36 V138
TM4
4x61 4.60x61 Q187
4x65 4.64x65 M191
ECL2
45x50 45.50x50 C210
45x52 45.52x52 E212
TM5
5x40 5.39x40 H224
5x43 5.42x43 F227
TM6
6x48 6.48x48 Y317
6x51 6.51x51 I320
6x52 6.52x52 S321
6x55 6.55x55 N324
TM7
7x38 7.39x38 H350
7x41 7.42x41 V353
7x42 7.43x42 Y354