Structure information

OX2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6TPJ

SPECIES

Homo sapiens

RESOLUTION

2.740

PREFERRED CHAIN

A

REFERENCE

10.1021/acs.jmedchem.9b01787

PUBLICATION DATE

Jan. 1, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
suvorexant C107 2.57x56 TM2 Van der Waals
suvorexant C107 2.57x56 TM2 polar (hydrogen bond with backbone)
suvorexant A110 2.60x59 TM2 Van der Waals
suvorexant A110 2.60x59 TM2 hydrophobic
suvorexant T111 2.61x60 TM2 polar (hydrogen bond)
suvorexant V114 2.64x63 TM2 Van der Waals
suvorexant I130 3.28x28 TM3 hydrophobic
suvorexant I130 3.28x28 TM3 Van der Waals
suvorexant P131 3.29x29 TM3 polar (hydrogen bond with backbone)
suvorexant P131 3.29x29 TM3 Van der Waals
suvorexant Q134 3.32x32 TM3 polar (hydrogen bond)
suvorexant T135 3.33x33 TM3 Van der Waals
suvorexant V138 3.36x36 TM3 Van der Waals
suvorexant Q187 4.60x61 TM4 polar (hydrogen bond)
suvorexant M191 4.64x65 TM4 Van der Waals
suvorexant E212 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
suvorexant H224 5.39x40 TM5 polar (hydrogen bond)
suvorexant F227 5.42x43 TM5 Van der Waals
suvorexant F227 5.42x43 TM5 aromatic (edge-to-face)
suvorexant Y317 6.48x48 TM6 Van der Waals
suvorexant I320 6.51x51 TM6 hydrophobic
suvorexant I320 6.51x51 TM6 Van der Waals
suvorexant N324 6.55x55 TM6 polar (hydrogen bond)
suvorexant N324 6.55x55 TM6 polar (hydrogen bond)
suvorexant H350 7.39x38 TM7 Van der Waals
suvorexant V353 7.42x41 TM7 Van der Waals
suvorexant V353 7.42x41 TM7 hydrophobic
suvorexant Y354 7.43x42 TM7 polar (hydrogen bond)

Ligands

suvorexant

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Residue Diagrams

V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7
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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX2 receptor
TM2
2x56 2.57x56 C107
2x59 2.60x59 A110
2x60 2.61x60 T111
2x63 2.64x63 V114
TM3
3x28 3.28x28 I130
3x29 3.29x29 P131
3x32 3.32x32 Q134
3x33 3.33x33 T135
3x36 3.36x36 V138
TM4
4x61 4.60x61 Q187
4x65 4.64x65 M191
ECL2
45x52 45.52x52 E212
TM5
5x40 5.39x40 H224
5x43 5.42x43 F227
TM6
6x48 6.48x48 Y317
6x51 6.51x51 I320
6x55 6.55x55 N324
TM7
7x38 7.39x38 H350
7x41 7.42x41 V353
7x42 7.43x42 Y354