Structure information

succinate receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6Z10

SPECIES

Rattus norvegicus

RESOLUTION

2.270

PREFERRED CHAIN

A

REFERENCE

10.1021/acs.jmedchem.0c01020

PUBLICATION DATE

Sept. 16, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4751488 Y26 1.39x39 TM1 polar (hydrogen bond)
CHEMBL4751488 Y26 1.39x39 TM1 Van der Waals
CHEMBL4751488 L75 2.60x60 TM2 hydrophobic
CHEMBL4751488 L75 2.60x60 TM2 Van der Waals
CHEMBL4751488 S78 2.63x63 TM2 Van der Waals
CHEMBL4751488 Y79 2.64x64 TM2 polar (hydrogen bond)
CHEMBL4751488 G82 2.67x67 TM2 Van der Waals
CHEMBL4751488 N83 23.49x49 ECL1 Van der Waals
CHEMBL4751488 W84 23.50x50 ECL1 Van der Waals
CHEMBL4751488 W84 23.50x50 ECL1 hydrophobic
CHEMBL4751488 N94 3.28x28 TM3 Van der Waals
CHEMBL4751488 R95 3.29x29 TM3 Van der Waals
CHEMBL4751488 L98 3.32x32 TM3 hydrophobic
CHEMBL4751488 L98 3.32x32 TM3 Van der Waals
CHEMBL4751488 C168 45.50x50 ECL2 hydrophobic
CHEMBL4751488 C168 45.50x50 ECL2 Van der Waals
CHEMBL4751488 Y244 6.51x51 TM6 polar (hydrogen bond)
CHEMBL4751488 Y244 6.51x51 TM6 Van der Waals
CHEMBL4751488 R276 7.39x38 TM7 polar (charge-assisted hydrogen bond)
CHEMBL4751488 F280 7.43x42 TM7 Van der Waals
CHEMBL4751488 F280 7.43x42 TM7 hydrophobic

Ligands

CHEMBL4751488

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Residue Diagrams

F N G L M G V I F E I G Y F A S L Y Y K 1 F N L S I S D L A F L C T L P M L I R S 2 F T L F L I S T Y L N A H L V Y R N S I 3 A I L I S L A V W V L V T L E V L P M 4 Y F F C M V S L P I L F G L L T L C L S Y 5 V L A V V I F S V L F T P Y H I M R N V 6 I P N V A S N L F A L P R T L I Y L C 7
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ICL1 K N W ICL1ECL1 N W T Y ECL1ICL2 P F R E H I L Q ICL2ECL2 P I E K G D S C V D Y A S S G ECL2ICL3 S Q Q ICL3ECL3 D S W P Q G ECL3N-term M A Q N L S N-termC-term T S F R L C-term C E N W L A L E N I L K K Y Y L S A F Y G I E F I V G M L G N F T V V F G Y L F C M N S S N V Y L F N L S I S D L A F L C T L P M L I R S Y A T G G D V L C I S N R Y V L H A N L Y T S I L F L T F I S I D R Y L L M K F K K E F A I L I S L A V W V L V T L E V L P M L T F I T S T N P K Y S L I Y S L C L T L L G F L I P L S V M C F F Y Y K M V V F L K K R Q A T V L S L N K P L R L V V L A V V I F S V L F T P Y H I M R N V R I A S R L C S Q K A I K C L Y I L T R P L A F L N S A V N P I F Y F L V G D H L F S Y F K F R D M K L R Q S L
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Residue Table


GPCRdb(A)
GPCRdb(A)
succinate receptor
TM1
1x39 1.39x39 Y26
TM2
2x60 2.60x60 L75
2x63 2.63x63 S78
2x64 2.64x64 Y79
2x67 2.67x67 G82
ECL1
23x49 23.49x49 N83
23x50 23.50x50 W84
TM3
3x28 3.28x28 N94
3x29 3.29x29 R95
3x32 3.32x32 L98
ECL2
45x50 45.50x50 C168
TM6
6x51 6.51x51 Y244
TM7
7x38 7.39x38 R276
7x42 7.43x42 F280