Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6Z4V

SPECIES

Rattus norvegicus

RESOLUTION

2.600

PREFERRED CHAIN

A

REFERENCE

10.1126/sciadv.abe5504

PUBLICATION DATE

Feb. 10, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
JMV431 L55 N-term polar (hydrogen bond)
JMV431 L55 N-term polar (hydrogen bond with backbone)
JMV431 F128 2.65x64 TM2 hydrophobic
JMV431 F128 2.65x64 TM2 Van der Waals
JMV431 H132 ECL1 polar (hydrogen bond with backbone)
JMV431 H132 ECL1 polar (hydrogen bond)
JMV431 H133 ECL1 polar (hydrogen bond)
JMV431 H133 ECL1 polar (hydrogen bond with backbone)
JMV431 Y146 3.29x29 TM3 polar (hydrogen bond)
JMV431 Y146 3.29x29 TM3 polar (hydrogen bond)
JMV431 M208 4.64x65 TM4 Van der Waals
JMV431 L213 ECL2 Van der Waals
JMV431 V224 ECL2 Van der Waals
JMV431 V224 ECL2 hydrophobic
JMV431 C225 45.50x50 ECL2 Van der Waals
JMV431 T226 45.51x51 ECL2 polar (hydrogen bond)
JMV431 T226 45.51x51 ECL2 polar (hydrogen bond)
JMV431 P227 45.52x52 ECL2 polar (hydrogen bond)
JMV431 T231 5.32x33 TM5 Van der Waals
JMV431 L234 5.35x36 TM5 Van der Waals
JMV431 I238 5.39x40 TM5 Van der Waals
JMV431 R327 6.54x54 TM6 polar (charge-assisted hydrogen bond)
JMV431 R328 6.55x55 TM6 polar (charge-assisted hydrogen bond)
JMV431 F331 6.58x58 TM6 polar (hydrogen bond)
JMV431 F331 6.58x58 TM6 polar (hydrogen bond with backbone)
JMV431 F331 6.58x58 TM6 polar (charge-assisted hydrogen bond)
JMV431 V332 6.59x59 TM6 Van der Waals
JMV431 S335 ECL3 polar (hydrogen bond with backbone)
JMV431 S335 ECL3 Van der Waals
JMV431 D336 ECL3 Van der Waals
JMV431 W339 ECL3 polar (hydrogen bond)
JMV431 F344 7.28x27 TM7 polar (hydrogen bond)
JMV431 Y347 7.31x30 TM7 polar (hydrogen bond)
JMV431 Y347 7.31x30 TM7 polar (hydrogen bond)
JMV431 H348 7.32x31 TM7 polar (hydrogen bond)
JMV431 Y351 7.35x34 TM7 polar (hydrogen bond)

Ligands

JMV431

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Residue Diagrams

S N G V T G V V F L A L Y I A T V L V K 1 G S L A L S D L L I L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A I P M 4 N L I S I V L M P F L F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I A S S V Y F L A N T L M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G L Q N R S G D G T H P G G L V C T P I V D ECL2ICL3 R V C T V G T H N G L E H S T F N M T I E ICL3ECL3 S D E Q W ECL3N-term M H L N S S V P Q G T P G E P D A Q P F S G P Q S E M E A T F L A L S L S N G S G N T S E S D T A G P N S D L D V N T D N-termC-term P G W R H R R K K R P T F S R K P N S M S S N H A F S T S A T R E T L Y C-term I Y S K V L V T A I Y L A L F V V G T V G N S V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A I P M L F T M T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M V H Q A A E Q G P G R V Q A L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I T T F L F D F Y H Y F Y M L T N A L F Y V S S A I N P I L Y N L V S A N F L S L C F R Q V T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F128
TM3
3x29 3.29x29 Y146
TM4
4x65 4.64x65 M208
ECL2
45x50 45.50x50 C225
45x51 45.51x51 T226
45x52 45.52x52 P227
TM5
5x33 5.32x33 T231
5x36 5.35x36 V234
5x40 5.39x40 I238
TM6
6x54 6.54x54 R327
6x55 6.55x55 R328
6x58 6.58x58 F331
6x59 6.59x59 C332
TM7
7x27 7.28x27 F344
7x30 7.31x30 Y347
7x31 7.32x31 H348
7x34 7.35x34 Y351