Structure information

M1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6ZFZ

SPECIES

Homo sapiens

RESOLUTION

2.170

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELL.2021.11.001

PUBLICATION DATE

Oct. 6, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL3354065 L81 2.60x59 TM2 hydrophobic
CHEMBL3354065 Y82 2.61x60 TM2 hydrophobic
CHEMBL3354065 Y85 2.64x63 TM2 hydrophobic
CHEMBL3354065 W91 23.50x50 ECL1 hydrophobic
CHEMBL3354065 D105 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL3354065 Y106 3.33x33 TM3 hydrophobic
CHEMBL3354065 Y106 3.33x33 TM3 Van der Waals
CHEMBL3354065 S109 3.36x36 TM3 Van der Waals
CHEMBL3354065 N110 3.37x37 TM3 Van der Waals
CHEMBL3354065 W157 4.57x57 TM4 hydrophobic
CHEMBL3354065 W157 4.57x57 TM4 Van der Waals
CHEMBL3354065 C178 45.50x50 ECL2 hydrophobic
CHEMBL3354065 C178 45.50x50 ECL2 Van der Waals
CHEMBL3354065 T196 5.46x461 TM5 Van der Waals
CHEMBL3354065 W378 6.48x48 TM6 hydrophobic
CHEMBL3354065 W378 6.48x48 TM6 Van der Waals
CHEMBL3354065 Y404 7.39x38 TM7 hydrophobic
CHEMBL3354065 Y404 7.39x38 TM7 Van der Waals
CHEMBL3354065 C407 7.42x41 TM7 Van der Waals
CHEMBL3354065 Y408 7.43x42 TM7 hydrophobic
CHEMBL3354065 Y408 7.43x42 TM7 Van der Waals

Ligands

CHEMBL3354065

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Residue Diagrams

L N G T V T A L S L L G T T I G I F A V 1 L S L A C A D L I I G F T S M N L Y T T Y 2 L L L N M V S A N S A V Y D L A L W L D 3 A A L M I G L A W L V S F V L W A P A I 4 Y L T C M V T V P L Y F A A M A T G F T I 5 S A I L L A F I L T W T P Y N I M V L V 6 M P N I T S N V Y C L W Y G L E W L T 7
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ICL1 T E L K ICL1ECL1 H W A L ECL1ICL2 P L S Y R A K R ICL2ECL2 E R T V L A G Q C Y I Q F L S ECL2ICL3 Q G S E T P G K G G G S S S S S E R S Q P G A E G S P E T P P G R C C R C C R A P R L L Q A Y S W K E E E E E D E G S M E S L T S S E G E E P G S E V V I K M P M V D P E A Q A P T K Q P P R S S P N T V K R P T K K G R D R A G K G Q K P R G K E Q L A K R K ICL3ECL3 K D C V ECL3N-term M N T S A P P A V S P N I T V L A P G K N-termC-term R W D K R R W R K I P K R P G S V H R T P S R Q C C-term G P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L T F S L V K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R L F R D T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M1 receptor
TM2
2x59 2.60x59 L81
2x60 2.61x60 Y82
2x63 2.64x63 Y85
ECL1
23x50 23.50x50 W91
TM3
3x32 3.32x32 D105
3x33 3.33x33 Y106
3x36 3.36x36 S109
3x37 3.37x37 N110
TM4
4x57 4.57x57 W157
ECL2
45x50 45.50x50 C178
TM5
5x461 5.46x461 A196
TM6
6x48 6.48x48 W378
TM7
7x38 7.39x38 Y404
7x41 7.42x41 C407
7x42 7.43x42 Y408