PDB
6ZG9
Resolution
2.5 Å
Released
Oct. 6, 2021
Receptor
M1
Class
A
Species
Homo sapiens
Ligand
Function
GSK1034702
Agonist
Reference
10.1016/J.CELL.2021.11.001

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
GSK1034702 F77 2.56x551 TM2 Van der Waals
GSK1034702 S78 2.57x56 TM2 Van der Waals
GSK1034702 L81 2.60x59 TM2 hydrophobic
GSK1034702 Y82 2.61x60 TM2 aromatic (pi-cation)
GSK1034702 Y82 2.61x60 TM2 hydrophobic
GSK1034702 Y85 2.64x63 TM2 Van der Waals
GSK1034702 W91 23.50x50 ECL1 Van der Waals
GSK1034702 L102 3.29x29 TM3 hydrophobic
GSK1034702 D105 3.32x32 TM3 polar (hydrogen bond)
GSK1034702 D105 3.32x32 TM3 polar (charge-charge)
GSK1034702 Y106 3.33x33 TM3 Van der Waals
GSK1034702 S109 3.36x36 TM3 Van der Waals
GSK1034702 C178 45.50x50 ECL2 polar (hydrogen bond with backbone)
GSK1034702 Y179 45.51x51 ECL2 Van der Waals
GSK1034702 I180 45.52x52 ECL2 hydrophobic
GSK1034702 W378 6.48x48 TM6 Van der Waals
GSK1034702 Y381 6.51x51 TM6 Van der Waals
GSK1034702 Y404 7.39x38 TM7 hydrophobic
GSK1034702 Y404 7.39x38 TM7 aromatic (pi-cation)
GSK1034702 Y408 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T E L K ICL1ECL1 H W A L ECL1ICL2 P L S Y R A K R ICL2ECL2 E R T V L A G Q C Y I Q F L S ECL2ICL3 Q G S E T P G K G G G S S S S S E R S Q P G A E G S P E T P P G R C C R C C R A P R L L Q A Y S W K E E E E E D E G S M E S L T S S E G E E P G S E V V I K M P M V D P E A Q A P T K Q P P R S S P N T V K R P T K K G R D R A G K G Q K P R G K E Q L A K R K ICL3ECL3 K D C V ECL3N-term M N T S A P P A V S P N I T V L A P G K N-termC-term R W D K R R W R K I P K R P G S V H R T P S R Q C C-term G P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L T F S L V K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R L F R D T L L L C
Helix box plot — Download: PNG | SVG L N G T V T A L S L L G T T I G I F A V 1 L S L A C A D L I I G F T S M N L Y T T Y 2 L L L N M V S A N S A V Y D L A L W L D 3 A A L M I G L A W L V S F V L W A P A I 4 Y L T C M V T V P L Y F A A M A T G F T I 5 S A I L L A F I L T W T P Y N I M V L V 6 M P N I T S N V Y C L W Y G L E W L T 7

GPCRdb(A)
GPCRdb(A)
M1 receptor
TM2
2x551 2.56x551 F77
2x56 2.57x56 S78
2x59 2.60x59 L81
2x60 2.61x60 Y82
2x63 2.64x63 Y85
ECL1
23x50 23.50x50 W91
TM3
3x29 3.29x29 L102
3x32 3.32x32 D105
3x33 3.33x33 Y106
3x36 3.36x36 S109
ECL2
45x50 45.50x50 C178
45x51 45.51x51 Y179
45x52 45.52x52 I180
TM6
6x48 6.48x48 W378
6x51 6.51x51 Y381
TM7
7x38 7.39x38 Y404
7x42 7.43x42 Y408