Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CKZ

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

PUBLICATION DATE

March 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
dopamine D103 3.32x32 TM3 polar (charge-charge)
dopamine I104 3.33x33 TM3 hydrophobic
dopamine S107 3.36x36 TM3 polar (charge-assisted hydrogen bond)
LY3154207 L112 3.41x41 TM3 hydrophobic
LY3154207 C115 3.44x44 TM3 polar (hydrogen bond)
LY3154207 V119 3.48x48 TM3 hydrophobic
LY3154207 W123 3.52x52 TM3 hydrophobic
LY3154207 L143 4.45x45 TM4 hydrophobic
dopamine S198 5.42x43 TM5 polar (hydrogen bond)
dopamine S202 5.46x461 TM5 polar (hydrogen bond)
LY3154207 I209 5.53x53 TM5 hydrophobic
dopamine F288 6.51x51 TM6 aromatic (edge-to-face)
dopamine F289 6.52x52 TM6 aromatic (edge-to-face)
dopamine W321 7.43x42 TM7 polar (charge-assisted hydrogen bond)

Ligands

dopamine

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LY3154207

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
3x41 3.41x41 L112
3x44 3.44x44 C115
3x48 3.48x48 V119
3x52 3.52x52 W123
TM4
4x45 4.45x45 L143
TM5
5x43 5.42x43 S198
5x461 5.46x461 S202
5x53 5.53x53 I209
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
TM7
7x42 7.43x42 W321