Structure information

EP2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CX2

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ABF1268

PUBLICATION DATE

May 5, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PGE<sub>2</sub> S28 1.39x39 TM1 polar (hydrogen bond)
PGE<sub>2</sub> S28 1.39x39 TM1 polar (hydrogen bond)
PGE<sub>2</sub> M31 1.42x42 TM1 hydrophobic
PGE<sub>2</sub> M31 1.42x42 TM1 Van der Waals
PGE<sub>2</sub> T82 2.54x54 TM2 polar (hydrogen bond)
PGE<sub>2</sub> I85 2.57x57 TM2 hydrophobic
PGE<sub>2</sub> I85 2.57x57 TM2 Van der Waals
PGE<sub>2</sub> S86 2.58x58 TM2 polar (hydrogen bond)
PGE<sub>2</sub> S86 2.58x58 TM2 Van der Waals
PGE<sub>2</sub> Y93 2.65x65 TM2 polar (hydrogen bond)
PGE<sub>2</sub> Y93 2.65x65 TM2 polar (hydrogen bond)
PGE<sub>2</sub> M116 3.32x32 TM3 hydrophobic
PGE<sub>2</sub> M116 3.32x32 TM3 Van der Waals
PGE<sub>2</sub> T123 3.39x39 TM3 Van der Waals
PGE<sub>2</sub> T185 ECL2 polar (hydrogen bond)
PGE<sub>2</sub> T185 ECL2 Van der Waals
PGE<sub>2</sub> L298 7.36x35 TM7 Van der Waals
PGE<sub>2</sub> L298 7.36x35 TM7 hydrophobic
PGE<sub>2</sub> R302 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGE<sub>2</sub> L304 7.42x41 TM7 Van der Waals
PGE<sub>2</sub> L304 7.42x41 TM7 hydrophobic
PGE<sub>2</sub> S305 7.43x42 TM7 polar (hydrogen bond)
PGE<sub>2</sub> N307 7.45x45 TM7 Van der Waals
PGE<sub>2</sub> S308 7.46x46 TM7 Van der Waals

Ligands

PGE<sub>2</sub>

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Residue Diagrams

L N G L V G A S F M V S S I A P S 1 T E L V F T D L L G T C L I S P V V L A 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W 7
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ICL1 W R G D V G C S A G R R S S L ICL1ECL1 Q T L V A L A P E ECL1ICL2 P Y F Y Q R R V ICL2ECL2 Y G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 N E T S S R K E K ECL3N-term M G N A S N D S Q S E D C E T R Q W L P P G E N-termC-term R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term S P A I S S V M F S A G V L G N L I A L A L L A R R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP2 receptor
TM1
1x39 1.39x39 S28
1x42 1.42x42 M31
TM2
2x54 2.54x54 T82
2x57 2.57x57 I85
2x58 2.58x58 S86
2x65 2.65x65 Y93
TM3
3x32 3.32x32 M116
3x39 3.39x39 T123
TM7
7x35 7.36x35 L298
7x39 7.40x39 R302
7x41 7.42x41 L304
7x42 7.43x42 S305
7x45 7.45x45 N307
7x46 7.46x46 S308