Structure information

EP2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CX2

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

PUBLICATION DATE

May 5, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Prostaglandin E2 S28 1.39x39 TM1 polar (charge-assisted hydrogen bond)
Prostaglandin E2 S28 1.39x39 TM1 polar (charge-assisted hydrogen bond)
Prostaglandin E2 T82 2.54x54 TM2 polar (hydrogen bond)
Prostaglandin E2 I85 2.57x56 TM2 hydrophobic
Prostaglandin E2 S86 2.58x57 TM2 polar (hydrogen bond)
Prostaglandin E2 Y93 2.65x64 TM2 polar (charge-assisted hydrogen bond)
Prostaglandin E2 Y93 2.65x64 TM2 polar (charge-assisted hydrogen bond)
Prostaglandin E2 M116 3.32x32 TM3 hydrophobic
Prostaglandin E2 T185 ECL2 polar (charge-assisted hydrogen bond)
Prostaglandin E2 L298 7.36x35 TM7 hydrophobic
Prostaglandin E2 R302 7.40x39 TM7 polar (charge-charge)
Prostaglandin E2 S305 7.43x42 TM7 polar (hydrogen bond)

Ligands

Prostaglandin E2

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Residue Diagrams

L N G L V G A S F M V S S I A P S 1 T E L V F T D L L G T L C I S P V V L A S 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W 7
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ICL1 W R G D V G C S A G R R S S L ICL1ECL1 Q T L V A L A P E ECL1ICL2 P Y F Y Q R R V ICL2ECL2 Y G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 N E T S S R K E K ECL3N-term M G N A S N D S Q S E D C E T R Q W L P P G E N-termC-term R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term S P A I S S V M F S A G V L G N L I A L A L L A R R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP2 receptor
TM1
1x39 1.39x39 S28
TM2
2x54 2.54x54 T82
2x56 2.57x56 I85
2x57 2.58x57 S86
2x64 2.65x64 Y93
TM3
3x32 3.32x32 M116
TM7
7x35 7.36x35 L298
7x39 7.40x39 R302
7x42 7.43x42 S305