Structure information

Y2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7DDZ

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-021-21030-9

PUBLICATION DATE

Jan. 27, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL1823578 Y110 2.64x63 TM2 hydrophobic
CHEMBL1823578 W116 23.50x50 ECL1 aromatic (face-to-edge)
CHEMBL1823578 P127 3.29x29 TM3 hydrophobic
CHEMBL1823578 Q130 3.32x32 TM3 polar (hydrogen bond)
CHEMBL1823578 Q130 3.32x32 TM3 Van der Waals
CHEMBL1823578 G131 3.33x33 TM3 Van der Waals
CHEMBL1823578 V134 3.36x36 TM3 hydrophobic
CHEMBL1823578 V134 3.36x36 TM3 Van der Waals
CHEMBL1823578 Q135 3.37x37 TM3 Van der Waals
CHEMBL1823578 L183 4.60x61 TM4 Van der Waals
CHEMBL1823578 L183 4.60x61 TM4 hydrophobic
CHEMBL1823578 R187 ECL2 Van der Waals
CHEMBL1823578 Y219 5.38x39 TM5 hydrophobic
CHEMBL1823578 Y219 5.38x39 TM5 Van der Waals
CHEMBL1823578 S220 5.39x40 TM5 polar (hydrogen bond)
CHEMBL1823578 S220 5.39x40 TM5 Van der Waals
CHEMBL1823578 S223 5.42x43 TM5 Van der Waals
CHEMBL1823578 L224 5.43x44 TM5 Van der Waals
CHEMBL1823578 L224 5.43x44 TM5 hydrophobic
CHEMBL1823578 L227 5.46x461 TM5 hydrophobic
CHEMBL1823578 L227 5.46x461 TM5 Van der Waals
CHEMBL1823578 H285 6.52x52 TM6 polar (hydrogen bond)
CHEMBL1823578 H285 6.52x52 TM6 Van der Waals
CHEMBL1823578 Q288 6.55x55 TM6 polar (hydrogen bond)
CHEMBL1823578 Q288 6.55x55 TM6 Van der Waals
CHEMBL1823578 F307 7.35x34 TM7 hydrophobic
CHEMBL1823578 F307 7.35x34 TM7 Van der Waals
CHEMBL1823578 H311 7.39x38 TM7 Van der Waals

Ligands

CHEMBL1823578

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Residue Diagrams

S N G I V G L L I I S C Y A L I L V V Q 1 A N L A V A D L L V N L T C L P F T L T Y 2 V T L T I T S V Q V A L G Q A Y P V L H 3 S F L I I G L A W G I S A L L A S P L 4 Y S F S I I G L P L V Y L I L L S S L S Y 5 V C V V V V F A V S W L P L H A F Q L A 6 L P N A F T S C M A I I H F V T F I L 7
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ICL1 K S M R ICL1ECL1 E W K M ECL1ICL2 H L E S K I ICL2ECL2 E Y S L I E I I P D F E I V A C T E K W P G E E K ECL2ICL3 A A ICL3ECL3 S Q V L ECL3N-term M G P I G A E A D E N Q T V E E M K V E Q Y G P Q T T P R G E L V P D P E P E L I D S T K L I N-termC-term L D A I H S E V S V T F K A K K N L E V R K N S G P N D S F T E A T N V C-term E V Q V V L I L A Y C S I I L L G V I G N S L V I H V V I K F T V T N F F I A N L A V A D L L V N T L C L P F T L T Y T L M G G P V L C H L V P Y A Q G L A V Q V S T I T L T V I A L D R H R C I V Y S K R I S F L I I G L A W G I S A L L A S P L A I F R S I Y G T V Y S L S S L L I L Y V L P L G I I S F S Y T R I W S K L K N H V S P G N D H Y H Q R R Q K T T K M L V C V V V V F A V S W L P L H A F Q L A V D I D D L K E Y K L I F T V F H I I A M C S T F A N P L L Y G W M N S N F L S E Q R Y R K A A F R C
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Residue Table


GPCRdb(A)
GPCRdb(A)
Y2 receptor
TM2
2x63 2.64x63 Y110
ECL1
23x50 23.50x50 W116
TM3
3x29 3.29x29 P127
3x32 3.32x32 Q130
3x33 3.33x33 G131
3x36 3.36x36 V134
3x37 3.37x37 Q135
TM4
4x61 4.60x61 L183
TM5
5x39 5.38x39 Y219
5x40 5.39x40 S220
5x43 5.42x43 S223
5x44 5.43x44 L224
5x461 5.46x461 L227
TM6
6x52 6.52x52 H285
6x55 6.55x55 Q288
TM7
7x34 7.35x34 F307
7x38 7.39x38 H311