Structure information

GIP receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7DTY

SPECIES

Homo sapiens

RESOLUTION

2.980

PREFERRED CHAIN

R

REFERENCE

10.7554/ELIFE.68719

PUBLICATION DATE

Aug. 4, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
GIP L35 N-term hydrophobic
GIP Y36 N-term polar (hydrogen bond)
GIP Y36 N-term Van der Waals
GIP W39 N-term aromatic (face-to-edge)
GIP W39 N-term Van der Waals
GIP D66 N-term Van der Waals
GIP M67 N-term Van der Waals
GIP M67 N-term hydrophobic
GIP Y68 N-term Van der Waals
GIP Y68 N-term hydrophobic
GIP W90 N-term Van der Waals
GIP R101 N-term Van der Waals
GIP R113 N-term Van der Waals
GIP H115 N-term Van der Waals
GIP N124 1.26x26 TM1 polar (hydrogen bond)
GIP N124 1.26x26 TM1 Van der Waals
GIP R131 1.33x33 TM1 polar (charge-assisted hydrogen bond)
GIP L134 1.36x36 TM1 Van der Waals
GIP L134 1.36x36 TM1 hydrophobic
GIP L137 1.39x39 TM1 Van der Waals
GIP L137 1.39x39 TM1 hydrophobic
GIP Q138 1.40x40 TM1 Van der Waals
GIP Y141 1.43x43 TM1 aromatic (edge-to-face)
GIP Y141 1.43x43 TM1 Van der Waals
GIP Y145 1.47x47 TM1 polar (hydrogen bond)
GIP R183 2.60x60 TM2 polar (charge-assisted hydrogen bond)
GIP R190 2.67x67 TM2 polar (charge-assisted hydrogen bond)
GIP G198 ECL1 Van der Waals
GIP P199 ECL1 polar (hydrogen bond with backbone)
GIP P199 ECL1 Van der Waals
GIP L201 ECL1 Van der Waals
GIP G202 ECL1 Van der Waals
GIP Q204 ECL1 Van der Waals
GIP Q224 3.37x37 TM3 Van der Waals
GIP Q224 3.37x37 TM3 polar (hydrogen bond)
GIP V227 3.40x40 TM3 Van der Waals
GIP V227 3.40x40 TM3 hydrophobic
GIP E288 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
GIP E288 45.52x52 ECL2 polar (hydrogen bond with backbone)
GIP R289 ECL2 polar (charge-assisted hydrogen bond)
GIP N290 ECL2 Van der Waals
GIP N290 ECL2 polar (hydrogen bond)
GIP W296 5.36x37 TM5 Van der Waals
GIP W296 5.36x37 TM5 hydrophobic
GIP R370 7.35x34 TM7 polar (charge-assisted hydrogen bond)
GIP L374 7.39x38 TM7 Van der Waals
GIP L374 7.39x38 TM7 hydrophobic
GIP E377 7.42x41 TM7 Van der Waals
GIP I378 7.43x42 TM7 hydrophobic
GIP I378 7.43x42 TM7 Van der Waals
GIP S381 7.46x45 TM7 polar (hydrogen bond)

Ligands

GIP

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Residue Diagrams

L L T A L S L S Y G V T Y M V Q L R E L 1 I N L F T S F M L R A A A I L S R D R L 2 V L L W T Y N A G V C Y Q T V I Q A T R 3 H F R Y Y L L G L W G A P A L F V I P W V 4 F I L F N I L I T M L I P T R I I W W I A 5 L T L V P L L G V H E V V F A P V 6 V S V L F G Q F S S L F I E F G L K A 7
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ICL1 R R L H ICL1ECL1 P R P G P Y L G D Q A L A L W N ECL1ICL2 V G G S E E G ICL2ECL2 N T Q C W E R N E V ECL2ICL3 Q M ICL3ECL3 T E E Q A R ECL3N-term M T T S P I L Q L L L R L S L C G L L L Q R A E T G S K G Q T A G E L Y Q R W E R Y R R E C Q E T L A A A E P P S G L A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N-termC-term Q L P E R A F R A L P S G S G P G E V P T S R G L S S G T L P G P G N E A S R E L E S Y C C-term N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F C T R N Y I H I N L F T S F M L R A A A I L S R D R L L Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R R C R D Y R L R L A R S T L T L V P L L G V H E V V F A P V G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E I R R C R L G E E V Q S E G W H H R R S L Q R
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Residue Table


GPCRdb(A)
GPCRdb(B)
GIP receptor
TM1
1x22 1.26x26 N124
1x29 1.33x33 R131
1x32 1.36x36 L134
1x35 1.39x39 L137
1x36 1.40x40 Q138
1x39 1.43x43 Y141
1x43 1.47x47 Y145
TM2
2x53 2.60x60 R183
2x60 2.67x67 R190
TM3
3x33 3.37x37 Q224
3x36 3.40x40 V227
ECL2
45x52 45.52x52 E288
TM5
5x41 5.36x37 W296
TM7
7x30 7.35x34 R370
7x34 7.39x38 L374
7x37 7.42x41 E377
7x38 7.43x42 I378
7x41 7.46x45 S381