PDB
7EPF
Resolution
2.7 Å
Released
June 23, 2021
Receptor
mGlu2
Class
C
Species
Homo sapiens
Ligand
Function
NAM597
NAM
Reference
10.1038/S41586-021-03641-W

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Ligand Amino Acid Generic Number Segment Interaction Type
NAM597 F623 2.56x56 TM2 Van der Waals
NAM597 L639 3.36x36 TM3 hydrophobic
NAM597 G640 3.37x37 TM3 Van der Waals
NAM597 F643 3.40x40 TM3 hydrophobic
NAM597 F643 3.40x40 TM3 aromatic (edge-to-face)
NAM597 H723 45.52x52 ECL2 Van der Waals
NAM597 R724 ECL2 Van der Waals
NAM597 D725 ECL2 Van der Waals
NAM597 M728 ECL2 hydrophobic
NAM597 S731 5.43x43 TM5 polar (hydrogen bond)
NAM597 L732 5.44x44 TM5 hydrophobic
NAM597 N735 5.47x47 TM5 polar (hydrogen bond)
NAM597 I772 6.49x49 TM6 Van der Waals
NAM597 W773 6.50x50 TM6 aromatic (edge-to-face)
NAM597 W773 6.50x50 TM6 hydrophobic
NAM597 F780 6.57x57 TM6 hydrophobic
NAM597 F780 6.57x57 TM6 aromatic (edge-to-face)
NAM597 M794 7.32x33 TM7 hydrophobic
NAM597 S797 7.35x36 TM7 Van der Waals
NAM597 V798 7.36x37 TM7 hydrophobic
NAM597 S801 7.39x40 TM7 Van der Waals

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ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
Helix box plot — Download: PNG | SVG L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7

GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM2
2x60 2.56x56 F623
TM3
3x32 3.36x36 L639
3x33 3.37x37 G640
3x36 3.40x40 F643
ECL2
45x52 45.52x52 H723
TM5
5x43 5.43x43 S731
5x44 5.44x44 L732
5x47 5.47x47 N735
TM6
6x47 6.49x49 I772
6x48 6.50x50 W773
6x55 6.57x57 F780
TM7
7x38 7.32x33 M794
7x41 7.35x36 S797
7x42 7.36x37 V798
7x45 7.39x40 S801