Structure information

CCK2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F8V

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-021-00866-8

PUBLICATION DATE

Oct. 13, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
desulfated gastrin-17 R57 1.35x35 TM1 polar (charge-assisted hydrogen bond)
desulfated gastrin-17 C107 2.57x56 TM2 Van der Waals
desulfated gastrin-17 T111 2.61x60 TM2 Van der Waals
desulfated gastrin-17 P114 2.64x63 TM2 Van der Waals
desulfated gastrin-17 P114 2.64x63 TM2 hydrophobic
desulfated gastrin-17 N115 2.65x64 TM2 polar (hydrogen bond)
desulfated gastrin-17 N115 2.65x64 TM2 polar (hydrogen bond)
desulfated gastrin-17 N115 2.65x64 TM2 polar (hydrogen bond with backbone)
desulfated gastrin-17 L116 2.66x65 TM2 Van der Waals
desulfated gastrin-17 L116 2.66x65 TM2 hydrophobic
desulfated gastrin-17 G118 ECL1 Van der Waals
desulfated gastrin-17 M134 3.32x32 TM3 Van der Waals
desulfated gastrin-17 V138 3.36x36 TM3 hydrophobic
desulfated gastrin-17 V138 3.36x36 TM3 Van der Waals
desulfated gastrin-17 Y189 4.60x61 TM4 polar (hydrogen bond)
desulfated gastrin-17 Y189 4.60x61 TM4 polar (hydrogen bond)
desulfated gastrin-17 V198 ECL2 polar (hydrogen bond with backbone)
desulfated gastrin-17 V198 ECL2 Van der Waals
desulfated gastrin-17 V202 ECL2 Van der Waals
desulfated gastrin-17 Q204 ECL2 polar (hydrogen bond)
desulfated gastrin-17 Q204 ECL2 Van der Waals
desulfated gastrin-17 V206 45.51x51 ECL2 Van der Waals
desulfated gastrin-17 V206 45.51x51 ECL2 hydrophobic
desulfated gastrin-17 H207 45.52x52 ECL2 Van der Waals
desulfated gastrin-17 L222 5.42x43 TM5 Van der Waals
desulfated gastrin-17 L222 5.42x43 TM5 hydrophobic
desulfated gastrin-17 V349 6.51x51 TM6 Van der Waals
desulfated gastrin-17 V349 6.51x51 TM6 hydrophobic
desulfated gastrin-17 Y350 6.52x52 TM6 Van der Waals
desulfated gastrin-17 Y350 6.52x52 TM6 hydrophobic
desulfated gastrin-17 A352 6.54x54 TM6 hydrophobic
desulfated gastrin-17 A352 6.54x54 TM6 Van der Waals
desulfated gastrin-17 N353 6.55x55 TM6 Van der Waals
desulfated gastrin-17 N353 6.55x55 TM6 polar (hydrogen bond)
desulfated gastrin-17 R356 6.58x58 TM6 Van der Waals
desulfated gastrin-17 P361 ECL3 hydrophobic
desulfated gastrin-17 P361 ECL3 Van der Waals
desulfated gastrin-17 H364 ECL3 aromatic (face-to-edge)
desulfated gastrin-17 H364 ECL3 polar (hydrogen bond)
desulfated gastrin-17 H364 ECL3 Van der Waals
desulfated gastrin-17 R365 ECL3 polar (charge-assisted hydrogen bond)
desulfated gastrin-17 S368 ECL3 polar (hydrogen bond)
desulfated gastrin-17 G369 7.32x31 TM7 Van der Waals
desulfated gastrin-17 I372 7.35x34 TM7 hydrophobic
desulfated gastrin-17 I372 7.35x34 TM7 Van der Waals
desulfated gastrin-17 H376 7.39x38 TM7 polar (hydrogen bond)
desulfated gastrin-17 H376 7.39x38 TM7 Van der Waals
desulfated gastrin-17 Y380 7.43x42 TM7 Van der Waals
desulfated gastrin-17 Y380 7.43x42 TM7 polar (hydrogen bond)

Ligands

desulfated gastrin-17

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Residue Diagrams

M N G G V S M L F I V A Y L T I R I A L 1 L S L A V S D L L L A A V C M P F T L L P 2 A V L S L T S V S V S V G M L Y S V A K 3 A A R V I V A T W L L S G L L M V P Y 4 Y A V A M V V G P I F F L L L L L L V S W 5 L V I V V L F F L C W L P V Y S A N T W 6 L P N V C A S A Y S L L H I F S I P A 7
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ICL1 R R L R ICL1ECL1 T F I F ECL1ICL2 P L Q A R V W Q ICL2ECL2 V V Q P V G P R V L Q C V H R W P ECL2ICL3 S D S Q S R V R N Q G G L P G A V H Q N G R C R P E T G A V G E D S D G C Y V Q L P R S R P A L E L T A L T A P G P G S G S R P T ICL3ECL3 P G A H R A L S ECL3N-term M E L L K L N R S V Q G T G P G P G A S L C R P G A P L L N S S S V G N L S C E P P R I R G A G T R E N-termC-term A R C C P R P P R A R P R A L P D E D P P T P S I A S L S R L S Y T T I S T L G P G C-term L E L A I R I T L Y A V I F L M S V G G N M L I I V V L G L S T V T N A F L L S L A V S D L L L A V A C M P F T L L P N L M G G T V I C K A V S Y L M G V S V S V S T L S L V A I A L E R Y S A I C R T R S H A A R V I V A T W L L S G L L M V P Y P V Y T S A R V R Q T W S V L L L L L L F F I P G V V M A V A Y G L I S R E L Y L G L R F D G D S D Q A K L L A K K R V V R M L L V I V V L F F L C W L P V Y S A N T W R A F D G G A P I S F I H L L S Y A S A C V N P L V Y C F M H R R C L E F R Q A T C
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCK2 receptor
TM1
1x35 1.35x35 R57
TM2
2x56 2.57x56 C107
2x60 2.61x60 T111
2x63 2.64x63 P114
2x64 2.65x64 N115
2x65 2.66x65 L116
TM3
3x32 3.32x32 M134
3x36 3.36x36 V138
TM4
4x61 4.60x61 Y189
ECL2
45x51 45.51x51 V206
45x52 45.52x52 H207
TM5
5x43 5.42x43 L222
TM6
6x51 6.51x51 V349
6x52 6.52x52 Y350
6x54 6.54x54 A352
6x55 6.55x55 N353
6x58 6.58x58 R356
TM7
7x31 7.32x31 G369
7x34 7.35x34 I372
7x38 7.39x38 H376
7x42 7.43x42 Y380