PDB
7JNI
Resolution
3.0 Å
Released
Feb. 9, 2022
Receptor
AT2
Class
A
Species
Homo sapiens
Ligand
Function
olodanrigan
Antagonist
Reference
10.1073/PNAS.2116289119

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Ligand Amino Acid Generic Number Segment Interaction Type
olodanrigan Y51 1.39x39 TM1 hydrophobic
olodanrigan W100 2.60x60 TM2 hydrophobic
olodanrigan Y103 2.63x63 TM2 hydrophobic
olodanrigan Y104 2.64x64 TM2 hydrophobic
olodanrigan Y108 ECL1 hydrophobic
olodanrigan G121 3.29x29 TM3 Van der Waals
olodanrigan L124 3.32x32 TM3 hydrophobic
olodanrigan T125 3.33x33 TM3 polar (hydrogen bond)
olodanrigan M128 3.36x36 TM3 hydrophobic
olodanrigan F129 3.37x37 TM3 hydrophobic
olodanrigan I132 3.40x40 TM3 hydrophobic
olodanrigan R182 4.64x65 TM4 Van der Waals
olodanrigan C195 45.50x50 ECL2 Van der Waals
olodanrigan K215 5.42x43 TM5 hydrophobic
olodanrigan K215 5.42x43 TM5 polar (charge-charge)
olodanrigan K215 5.42x43 TM5 polar (hydrogen bond)
olodanrigan G219 5.46x461 TM5 Van der Waals
olodanrigan W269 6.48x48 TM6 hydrophobic
olodanrigan W269 6.48x48 TM6 aromatic (edge-to-face)
olodanrigan F272 6.51x51 TM6 hydrophobic
olodanrigan F272 6.51x51 TM6 aromatic (edge-to-face)
olodanrigan H273 6.52x52 TM6 Van der Waals
olodanrigan I304 7.39x38 TM7 hydrophobic
olodanrigan G307 7.42x41 TM7 Van der Waals
olodanrigan F308 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K G P K K ICL1ECL1 Y D W L F ECL1ICL2 P F L S Q R R ICL2ECL2 D V R T I E Y L G V N A C I M A F P P E ECL2ICL3 N S Y ICL3ECL3 V I N ECL3N-term M K G N S T L A T T S K N I T S G L H F G L V N I S G N N E S T L N C S Q K P S D K H L N-termC-term I T W L Q G K R E S M S C R K S S S L R E M E T F V S C-term D A I P I L Y Y I I F V I G F L V N I V V V T L F C C Q V S S I Y I F N L A V A D L L L L A T L P L W A T Y Y S Y R G P V M C K V F G S F L T L N M F A S I F F I T C M S V D R Y Q S V I Y N P W Q A S Y I V P L V W C M A C L S S L P T F Y F R K Y A Q W S A G I A L M K N I L G F I I P L I F I A T C Y F G I R K H L L K T G K N R I T R D Q V L K M A A A V V L A F I I C W L P F H V L T F L D A L A W M G S C E V I A V I D L A L P F A I L L G F T N S C V N P F L Y C F V G N R L R S P F Q Q K V F R V
Helix box plot — Download: PNG | SVG I N V L F G I V F I I Y Y L I P I A D 1 F N L A V A D L L L L A T L P L W A T Y 2 C T I F F I S A F M N L T L F S G F V K 3 A S Y I V P L V W C M A C L S S L P T 4 Y C T A I F I L P I I F G L I N K M L A I 5 A A V V L A F I I C W L P F H V L T F L 6 F P N V C S N T F G L L I A F P L A L 7

GPCRdb(A)
GPCRdb(A)
AT2 receptor
TM1
1x39 1.39x39 Y51
TM2
2x60 2.60x60 W100
2x63 2.63x63 Y103
2x64 2.64x64 Y104
TM3
3x29 3.29x29 G121
3x32 3.32x32 L124
3x33 3.33x33 T125
3x36 3.36x36 M128
3x37 3.37x37 F129
3x40 3.40x40 I132
TM4
4x65 4.64x65 R182
ECL2
45x50 45.50x50 C195
TM5
5x43 5.42x43 K215
5x461 5.46x461 G219
TM6
6x48 6.48x48 W269
6x51 6.51x51 F272
6x52 6.52x52 H273
TM7
7x38 7.39x38 I304
7x41 7.42x41 G307
7x42 7.43x42 F308