Structure information

AT2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7JNI

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1073/PNAS.2116289119

PUBLICATION DATE

Feb. 9, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
olodanrigan Y51 1.39x39 TM1 aromatic (face-to-edge)
olodanrigan W100 2.60x60 TM2 hydrophobic
olodanrigan Y103 2.63x63 TM2 hydrophobic
olodanrigan Y108 ECL1 hydrophobic
olodanrigan L124 3.32x32 TM3 hydrophobic
olodanrigan T125 3.33x33 TM3 Van der Waals
olodanrigan T125 3.33x33 TM3 polar (hydrogen bond)
olodanrigan M128 3.36x36 TM3 hydrophobic
olodanrigan M128 3.36x36 TM3 Van der Waals
olodanrigan F129 3.37x37 TM3 Van der Waals
olodanrigan F129 3.37x37 TM3 hydrophobic
olodanrigan R182 4.64x65 TM4 Van der Waals
olodanrigan C195 45.50x50 ECL2 Van der Waals
olodanrigan K215 5.42x43 TM5 polar (charge-assisted hydrogen bond)
olodanrigan W269 6.48x48 TM6 aromatic (edge-to-face)
olodanrigan W269 6.48x48 TM6 Van der Waals
olodanrigan F272 6.51x51 TM6 Van der Waals
olodanrigan F272 6.51x51 TM6 aromatic (face-to-edge)
olodanrigan I304 7.39x38 TM7 Van der Waals
olodanrigan I304 7.39x38 TM7 hydrophobic
olodanrigan F308 7.43x42 TM7 hydrophobic
olodanrigan F308 7.43x42 TM7 Van der Waals

Ligands

olodanrigan

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Residue Diagrams

I N V L F G I V F I I Y Y L I P I A D 1 F N L A V A D L L L L A T L P L W A T Y 2 C T I F F I S A F M N L T L F S G F V K 3 A S Y I V P L V W C M A C L S S L P T 4 Y C T A I F I L P I I F G L I N K M L A I 5 A A V V L A F I I C W L P F H V L T F L 6 F P N V C S N T F G L L I A F P L A L 7
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ICL1 K G P K K ICL1ECL1 Y D W L F ECL1ICL2 P F L S Q R R ICL2ECL2 D V R T I E Y L G V N A C I M A F P P E ECL2ICL3 N S Y ICL3ECL3 V I N ECL3N-term M K G N S T L A T T S K N I T S G L H F G L V N I S G N N E S T L N C S Q K P S D K H L N-termC-term I T W L Q G K R E S M S C R K S S S L R E M E T F V S C-term D A I P I L Y Y I I F V I G F L V N I V V V T L F C C Q V S S I Y I F N L A V A D L L L L A T L P L W A T Y Y S Y R G P V M C K V F G S F L T L N M F A S I F F I T C M S V D R Y Q S V I Y N P W Q A S Y I V P L V W C M A C L S S L P T F Y F R K Y A Q W S A G I A L M K N I L G F I I P L I F I A T C Y F G I R K H L L K T G K N R I T R D Q V L K M A A A V V L A F I I C W L P F H V L T F L D A L A W M G S C E V I A V I D L A L P F A I L L G F T N S C V N P F L Y C F V G N R L R S P F Q Q K V F R V
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Residue Table


GPCRdb(A)
GPCRdb(A)
AT2 receptor
TM1
1x39 1.39x39 Y51
TM2
2x60 2.60x60 W100
2x63 2.63x63 Y103
TM3
3x32 3.32x32 L124
3x33 3.33x33 T125
3x36 3.36x36 M128
3x37 3.37x37 F129
TM4
4x65 4.64x65 R182
ECL2
45x50 45.50x50 C195
TM5
5x43 5.42x43 K215
TM6
6x48 6.48x48 W269
6x51 6.51x51 F272
TM7
7x38 7.39x38 I304
7x42 7.43x42 F308