Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7JOZ

SPECIES

Homo sapiens

RESOLUTION

3.800

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-021-23519-9

PUBLICATION DATE

April 14, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4453318 V100 3.29x29 TM3 hydrophobic
CHEMBL4453318 I104 3.33x33 TM3 hydrophobic
CHEMBL4453318 C186 45.50x50 ECL2 polar (hydrogen bond with backbone)
CHEMBL4453318 C186 45.50x50 ECL2 Van der Waals
CHEMBL4453318 D187 45.51x51 ECL2 Van der Waals
CHEMBL4453318 S188 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL4453318 S188 45.52x52 ECL2 Van der Waals
CHEMBL4453318 L190 ECL2 hydrophobic
CHEMBL4453318 L190 ECL2 Van der Waals
CHEMBL4453318 S202 5.46x461 TM5 Van der Waals
CHEMBL4453318 F288 6.51x51 TM6 Van der Waals
CHEMBL4453318 F288 6.51x51 TM6 hydrophobic
CHEMBL4453318 F289 6.52x52 TM6 hydrophobic
CHEMBL4453318 F289 6.52x52 TM6 Van der Waals
CHEMBL4453318 N292 6.55x55 TM6 Van der Waals

Ligands

CHEMBL4453318

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x29 3.29x29 V100
3x33 3.33x33 I104
ECL2
45x50 45.50x50 C186
45x51 45.51x51 D187
45x52 45.52x52 S188
TM5
5x461 5.46x461 S202
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292