Structure information

D2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7JVR

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2021.01.027

PUBLICATION DATE

Feb. 24, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
bromocriptine F110 3.28x28 TM3 hydrophobic
bromocriptine V115 3.33x33 TM3 hydrophobic
bromocriptine T119 3.37x37 TM3 polar (hydrogen bond)
bromocriptine I183 45.51x51 ECL2 hydrophobic
bromocriptine I183 45.51x51 ECL2 Van der Waals
bromocriptine I184 45.52x52 ECL2 polar (hydrogen bond with backbone)
bromocriptine I184 45.52x52 ECL2 Van der Waals
bromocriptine V190 5.39x40 TM5 hydrophobic
bromocriptine V190 5.39x40 TM5 Van der Waals
bromocriptine S197 5.46x461 TM5 Van der Waals
bromocriptine F389 6.51x51 TM6 hydrophobic
bromocriptine F389 6.51x51 TM6 Van der Waals
bromocriptine F390 6.52x52 TM6 aromatic (edge-to-face)
bromocriptine F390 6.52x52 TM6 Van der Waals
bromocriptine H393 6.55x55 TM6 Van der Waals
bromocriptine Y408 7.35x34 TM7 hydrophobic
bromocriptine Y408 7.35x34 TM7 Van der Waals
bromocriptine T412 7.39x38 TM7 Van der Waals
bromocriptine Y416 7.43x42 TM7 Van der Waals

Ligands

bromocriptine

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Residue Diagrams

V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7
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ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
D2 receptor
TM3
3x28 3.28x28 F110
3x33 3.33x33 V115
3x37 3.37x37 T119
ECL2
45x51 45.51x51 I183
45x52 45.52x52 I184
TM5
5x40 5.39x40 V190
5x461 5.46x461 S197
TM6
6x51 6.51x51 F389
6x52 6.52x52 F390
6x55 6.55x55 H393
TM7
7x34 7.35x34 Y408
7x38 7.39x38 T412
7x42 7.43x42 Y416