Structure information

DP2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7M8W

SPECIES

Homo sapiens

RESOLUTION

2.610

PREFERRED CHAIN

A

REFERENCE

10.1073/PNAS.2102813118

PUBLICATION DATE

Aug. 25, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> F87 2.60x60 TM2 hydrophobic
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> F90 2.63x63 TM2 hydrophobic
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> F111 3.32x32 TM3 hydrophobic
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> F112 3.33x33 TM3 hydrophobic
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> R170 4.64x65 TM4 polar (charge-assisted hydrogen bond)
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> M181 ECL2 Van der Waals
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> C182 45.50x50 ECL2 Van der Waals
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> C182 45.50x50 ECL2 polar (hydrogen bond with backbone)
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> Y183 45.51x51 ECL2 hydrophobic
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> Y183 45.51x51 ECL2 Van der Waals
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> Y184 45.52x52 ECL2 Van der Waals
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> Y184 45.52x52 ECL2 polar (hydrogen bond)
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> Y262 6.51x51 TM6 polar (hydrogen bond)
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> Y262 6.51x51 TM6 Van der Waals
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> L286 7.35x34 TM7 Van der Waals
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> L286 7.35x34 TM7 hydrophobic
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> P287 7.36x35 TM7 Van der Waals
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> P287 7.36x35 TM7 hydrophobic
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> T290 7.39x38 TM7 Van der Waals
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> F294 7.43x42 TM7 Van der Waals
15(<i>R</i>)-15-methyl-PGD<sub>2</sub> F294 7.43x42 TM7 hydrophobic

Ligands

15(<i>R</i>)-15-methyl-PGD<sub>2</sub>

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Residue Diagrams

G N E V L G L L S A L G H L L V A A H D 1 L H L A L S D L L A S A S L P F F T Y F 2 A S L L F G S A F M N L F F I S S H L K 3 A H K V C L V L W A L A V L N T V P Y 4 H S S A I I A L P V L F A L L F K S V A L 5 A A V V A A F A L C W G P Y H V F S L L 6 V P N A V S N F F A L S T V F P L G R 7
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ICL1 M R Q ICL1ECL1 H S W E L ECL1ICL2 P V W A Q N H R ICL2ECL2 D T I S R L D G R I M C Y Y N V L L L N P G P ECL2ICL3 G R R R ICL3ECL3 H A N P G ECL3N-term M S A N A T L K P L C P I L E Q M S R L Q S H S N T S I R Y I N-termC-term V L V D D S E L G G A G S S R R R R T S S T A R S A S P L A L C S R P E E P R G P A R L L G W L L G S C A A S P Q T G P L N R A L S S T S S C-term D H A A V L L H G L A S L L G L V E N G V I L F V V G C R T V V T T W V L H L A L S D L L A S A S L P F F T Y F L A V G G T T F C K L H S S I F F L N M F A S G F L L S A I S L D R C L Q V V R T V A A A H K V C L V L W A L A V L N T V P Y F V F R D R D A T C N S R Q V A L A V S K F L L A F L V P L A I I A S S H A A V S L R L Q H R P G R F V R L V A A V V A A F A L C W G P Y H V F S L L E A R A L R P L V W R G L P F V T S L A F F N S V A N P V L Y V L T C P D L R R V L E M L R K S L R T S
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Residue Table


GPCRdb(A)
GPCRdb(A)
DP2 receptor
TM2
2x60 2.60x60 F87
2x63 2.63x63 F90
TM3
3x32 3.32x32 F111
3x33 3.33x33 F112
TM4
4x65 4.64x65 R170
ECL2
45x50 45.50x50 C182
45x51 45.51x51 Y183
45x52 45.52x52 Y184
TM6
6x51 6.51x51 Y262
TM7
7x34 7.35x34 L286
7x35 7.36x35 P287
7x38 7.39x38 T290
7x42 7.43x42 F294