Structure information

P2Y12 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7PP1

SPECIES

Homo sapiens

RESOLUTION

2.780

PREFERRED CHAIN

A

REFERENCE

10.1016/j.bcp.2022.115291

PUBLICATION DATE

Nov. 2, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
selatogrel Y105 3.33x33 TM3 hydrophobic
selatogrel Y109 3.37x37 TM3 hydrophobic
selatogrel L155 4.56x56 TM4 hydrophobic
selatogrel N159 4.60x60 TM4 Van der Waals
selatogrel N159 4.60x60 TM4 polar (hydrogen bond)
selatogrel H187 5.36x36 TM5 Van der Waals
selatogrel H187 5.36x36 TM5 polar (hydrogen bond)
selatogrel V190 5.39x39 TM5 hydrophobic
selatogrel V190 5.39x39 TM5 Van der Waals
selatogrel N191 5.40x40 TM5 Van der Waals
selatogrel C194 5.43x43 TM5 Van der Waals
selatogrel F252 6.51x51 TM6 Van der Waals
selatogrel F252 6.51x51 TM6 aromatic (face-to-edge)
selatogrel A255 6.54x54 TM6 Van der Waals
selatogrel A255 6.54x54 TM6 hydrophobic
selatogrel R256 6.55x55 TM6 polar (charge-assisted hydrogen bond)
selatogrel Y259 6.58x58 TM6 Van der Waals
selatogrel T260 6.59x59 TM6 Van der Waals
selatogrel K280 7.35x34 TM7 polar (charge-assisted hydrogen bond)
selatogrel T283 7.38x37 TM7 Van der Waals

Ligands

selatogrel

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Residue Diagrams

G N T I L G V F F L V T Y L L P F L V Q 1 K N T V I S D L L M I L T F P F K I L S 2 L G L F S I S I Y M T F Y F I V S T V Q 3 A K I L S V V I W A F M F L L S L P N M 4 Y C V I V I L F N I W F I V Q C I Y N V 5 V F I I I A V F I F C F V P F H F A R I P 6 F P D L C A N L S T L W L T S E K V Y 7
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ICL1 R S K ICL1ECL1 L G T ECL1ICL2 P F K T S N P K ICL2ECL2 N R Q P R D K N V K K C S F L K S ECL2ICL3 R G V G K V ICL3ECL3 D V F ECL3N-term M Q A V D N L T S A P G N T S L C T R D N-termC-term L K C P N S A T S L S Q D N R K K E Q D G G D P N E E T P M C-term Y K I T Q V L F P L L Y T V L F F V G L I T N G L A M R I F F Q I S N F I I F L K N T V I S D L L M I L T F P F K I L S D A K G P L R T F V C Q V T S V I F Y F T M Y I S I S F L G L I T I D R Y Q K T T R N L L G A K I L S V V I W A F M F L L S L P N M I L T E F G L V W H E I V N Y I C Q V I F W I N F L I V I V C Y T L I T K E L Y R S Y V R T P R K K V N V K V F I I I A V F F I C F V P F H F A R I P Y T L S Q T R D C T A E N T L F Y V K E S T L W L T S L N A C L D P F I Y F F L C K S L I S F R N S M
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Residue Table


GPCRdb(A)
GPCRdb(A)
P2Y12 receptor
TM3
3x33 3.33x33 Y105
3x37 3.37x37 Y109
TM4
4x56 4.56x56 L155
4x60 4.60x60 N159
TM5
5x36 5.36x36 H187
5x39 5.39x39 V190
5x40 5.40x40 N191
5x43 5.43x43 C194
TM6
6x51 6.51x51 F252
6x54 6.54x54 A255
6x55 6.55x55 R256
6x58 6.58x58 Y259
6x59 6.59x59 T260
TM7
7x34 7.35x34 K280
7x37 7.38x37 T283