Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TYW

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ABM9609

PUBLICATION DATE

March 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
calcitonin (salmon synthetic) Y41 N-term hydrophobic
calcitonin (salmon synthetic) W79 N-term hydrophobic
calcitonin (salmon synthetic) F99 N-term hydrophobic
calcitonin (salmon synthetic) P100 N-term hydrophobic
calcitonin (salmon synthetic) D101 N-term polar (charge-assisted hydrogen bond)
calcitonin (salmon synthetic) F102 N-term hydrophobic
calcitonin (salmon synthetic) F102 N-term Van der Waals
calcitonin (salmon synthetic) E123 N-term Van der Waals
calcitonin (salmon synthetic) W128 N-term polar (hydrogen bond)
calcitonin (salmon synthetic) W128 N-term Van der Waals
calcitonin (salmon synthetic) S129 N-term polar (hydrogen bond with backbone)
calcitonin (salmon synthetic) S129 N-term Van der Waals
calcitonin (salmon synthetic) S129 N-term polar (hydrogen bond)
calcitonin (salmon synthetic) Y131 N-term hydrophobic
calcitonin (salmon synthetic) Y131 N-term Van der Waals
calcitonin (salmon synthetic) N135 N-term Van der Waals
calcitonin (salmon synthetic) K141 1.32x32 TM1 Van der Waals
calcitonin (salmon synthetic) L142 1.33x33 TM1 Van der Waals
calcitonin (salmon synthetic) L142 1.33x33 TM1 hydrophobic
calcitonin (salmon synthetic) A145 1.36x36 TM1 Van der Waals
calcitonin (salmon synthetic) Y146 1.37x37 TM1 hydrophobic
calcitonin (salmon synthetic) Y146 1.37x37 TM1 Van der Waals
calcitonin (salmon synthetic) L148 1.39x39 TM1 Van der Waals
calcitonin (salmon synthetic) L148 1.39x39 TM1 hydrophobic
calcitonin (salmon synthetic) Y149 1.40x40 TM1 Van der Waals
calcitonin (salmon synthetic) Y149 1.40x40 TM1 hydrophobic
calcitonin (salmon synthetic) I198 2.64x64 TM2 hydrophobic
calcitonin (salmon synthetic) I198 2.64x64 TM2 Van der Waals
calcitonin (salmon synthetic) H201 2.67x67 TM2 polar (hydrogen bond)
calcitonin (salmon synthetic) L202 2.68x68 TM2 Van der Waals
calcitonin (salmon synthetic) V206 ECL1 Van der Waals
calcitonin (salmon synthetic) V206 ECL1 hydrophobic
calcitonin (salmon synthetic) G209 ECL1 Van der Waals
calcitonin (salmon synthetic) V212 ECL1 Van der Waals
calcitonin (salmon synthetic) V212 ECL1 hydrophobic
calcitonin (salmon synthetic) H226 3.36x36 TM3 Van der Waals
calcitonin (salmon synthetic) Y234 3.44x44 TM3 hydrophobic
calcitonin (salmon synthetic) L291 45.52x52 ECL2 Van der Waals
calcitonin (salmon synthetic) L291 45.52x52 ECL2 hydrophobic
calcitonin (salmon synthetic) S292 ECL2 Van der Waals
calcitonin (salmon synthetic) V293 ECL2 Van der Waals
calcitonin (salmon synthetic) V293 ECL2 polar (hydrogen bond with backbone)
calcitonin (salmon synthetic) E294 ECL2 polar (charge-assisted hydrogen bond)
calcitonin (salmon synthetic) L298 5.36x37 TM5 Van der Waals
calcitonin (salmon synthetic) Y299 5.37x38 TM5 hydrophobic
calcitonin (salmon synthetic) Y299 5.37x38 TM5 Van der Waals
calcitonin (salmon synthetic) H302 5.40x40 TM5 polar (hydrogen bond)
calcitonin (salmon synthetic) V305 5.43x43 TM5 Van der Waals
calcitonin (salmon synthetic) M306 5.44x44 TM5 Van der Waals
calcitonin (salmon synthetic) F356 6.53x53 TM6 hydrophobic
calcitonin (salmon synthetic) F356 6.53x53 TM6 Van der Waals
calcitonin (salmon synthetic) P360 ECL3 polar (hydrogen bond with backbone)
calcitonin (salmon synthetic) P360 ECL3 Van der Waals
calcitonin (salmon synthetic) W361 ECL3 hydrophobic
calcitonin (salmon synthetic) W361 ECL3 Van der Waals
calcitonin (salmon synthetic) R362 ECL3 polar (hydrogen bond with backbone)
calcitonin (salmon synthetic) R362 ECL3 Van der Waals
calcitonin (salmon synthetic) Y372 7.38x37 TM7 Van der Waals
calcitonin (salmon synthetic) H377 7.43x42 TM7 Van der Waals
calcitonin (salmon synthetic) I380 7.46x45 TM7 Van der Waals

Ligands

calcitonin (salmon synthetic)

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x28 1.32x32 K141
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
TM2
2x57 2.64x64 I198
2x60 2.67x67 H201
2x61 2.68x68 L202
TM3
3x32 3.36x36 H226
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x41 5.36x37 L298
5x42 5.37x38 Y299
5x44 5.40x40 H302
5x47 5.43x43 V305
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356
TM7
7x33 7.38x37 Y372
7x38 7.43x42 H377
7x41 7.46x45 I380