Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7U2K

SPECIES

Mus musculus

RESOLUTION

3.300

PREFERRED CHAIN

D

REFERENCE

10.1038/S41586-022-05588-Y

PUBLICATION DATE

Dec. 7, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL147044 I144 3.29x29 TM3 hydrophobic
CHEMBL147044 D147 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL147044 Y148 3.33x33 TM3 Van der Waals
CHEMBL147044 Y148 3.33x33 TM3 hydrophobic
CHEMBL147044 M151 3.36x36 TM3 Van der Waals
CHEMBL147044 M151 3.36x36 TM3 hydrophobic
CHEMBL147044 S154 3.39x39 TM3 Van der Waals
CHEMBL147044 W293 6.48x48 TM6 hydrophobic
CHEMBL147044 W293 6.48x48 TM6 Van der Waals
CHEMBL147044 H297 6.52x52 TM6 Van der Waals
CHEMBL147044 I322 7.39x38 TM7 hydrophobic
CHEMBL147044 I322 7.39x38 TM7 Van der Waals
CHEMBL147044 G325 7.42x41 TM7 Van der Waals
CHEMBL147044 Y326 7.43x42 TM7 hydrophobic
CHEMBL147044 Y326 7.43x42 TM7 Van der Waals
CHEMBL147044 S329 7.46x46 TM7 Van der Waals
CHEMBL147044 S329 7.46x46 TM7 polar (hydrogen bond)

Ligands

CHEMBL147044

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
3x39 3.39x39 S154
TM6
6x48 6.48x48 W293
6x52 6.52x52 H297
TM7
7x38 7.39x38 I322
7x41 7.42x41 G325
7x42 7.43x42 Y326
7x46 7.46x46 S329