Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7V3Z

SPECIES

Homo sapiens

RESOLUTION

3.290

PREFERRED CHAIN

A

REFERENCE

10.1021/JACS.1C06847

PUBLICATION DATE

Nov. 24, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CP55940 F170 2.57x57 TM2 aromatic (edge-to-face)
CP55940 S173 2.60x60 TM2 Van der Waals
CP55940 S173 2.60x60 TM2 polar (hydrogen bond)
CP55940 F174 2.61x61 TM2 hydrophobic
CP55940 F174 2.61x61 TM2 Van der Waals
CP55940 F177 2.64x64 TM2 Van der Waals
CP55940 F177 2.64x64 TM2 hydrophobic
CP55940 F189 3.25x25 TM3 hydrophobic
CP55940 F189 3.25x25 TM3 Van der Waals
CP55940 K192 3.28x28 TM3 polar (hydrogen bond with backbone)
CP55940 K192 3.28x28 TM3 Van der Waals
CP55940 L193 3.29x29 TM3 Van der Waals
CP55940 L193 3.29x29 TM3 polar (hydrogen bond with backbone)
CP55940 V196 3.32x32 TM3 Van der Waals
CP55940 V196 3.32x32 TM3 hydrophobic
CP55940 I267 ECL2 Van der Waals
CP55940 I267 ECL2 polar (hydrogen bond with backbone)
CP55940 F268 ECL2 Van der Waals
CP55940 F268 ECL2 aromatic (edge-to-face)
CP55940 P269 ECL2 Van der Waals
CP55940 Y275 5.39x39 TM5 Van der Waals
CP55940 Y275 5.39x39 TM5 hydrophobic
CP55940 W279 5.43x43 TM5 hydrophobic
CP55940 W279 5.43x43 TM5 Van der Waals
CP55940 F501 7.35x34 TM7 hydrophobic
CP55940 F501 7.35x34 TM7 Van der Waals
CP55940 S505 7.39x38 TM7 polar (hydrogen bond)
CP55940 S505 7.39x38 TM7 Van der Waals

Ligands

CP55940

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Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x60 2.60x60 S173
2x61 2.61x61 F174
2x64 2.64x64 F177
TM3
3x25 3.25x25 F189
3x28 3.28x28 K192
3x29 3.29x29 L193
3x32 3.32x32 V196
TM5
5x39 5.39x39 Y275
5x43 5.43x43 W279
TM7
7x34 7.35x34 F379
7x38 7.39x38 S383