Structure information

S1P1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VIG

SPECIES

Homo sapiens

RESOLUTION

2.890

PREFERRED CHAIN

F

REFERENCE

10.1073/PNAS.2117716119

PUBLICATION DATE

Sept. 28, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
icanbelimod Y29 N-term polar (hydrogen bond)
icanbelimod N101 2.60x60 TM2 Van der Waals
icanbelimod N101 2.60x60 TM2 polar (hydrogen bond)
icanbelimod S105 ECL1 Van der Waals
icanbelimod G106 23.47x47 ECL1 Van der Waals
icanbelimod G106 23.47x47 ECL1 polar (hydrogen bond with backbone)
icanbelimod T109 23.50x50 ECL1 polar (hydrogen bond)
icanbelimod T109 23.50x50 ECL1 Van der Waals
icanbelimod R120 3.28x28 TM3 Van der Waals
icanbelimod E121 3.29x29 TM3 Van der Waals
icanbelimod F125 3.33x33 TM3 aromatic (face-to-face)
icanbelimod F125 3.33x33 TM3 Van der Waals
icanbelimod L128 3.36x36 TM3 hydrophobic
icanbelimod L128 3.36x36 TM3 Van der Waals
icanbelimod S129 3.37x37 TM3 Van der Waals
icanbelimod V194 ECL2 Van der Waals
icanbelimod L195 ECL2 hydrophobic
icanbelimod L195 ECL2 Van der Waals
icanbelimod F210 5.47x47 TM5 hydrophobic
icanbelimod W269 6.48x48 TM6 aromatic (edge-to-face)
icanbelimod W269 6.48x48 TM6 Van der Waals
icanbelimod L272 6.51x51 TM6 Van der Waals
icanbelimod L276 6.55x55 TM6 Van der Waals
icanbelimod L297 7.39x38 TM7 hydrophobic
icanbelimod L297 7.39x38 TM7 Van der Waals

Ligands

icanbelimod

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Residue Diagrams

I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7
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ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM2
2x60 2.60x60 N101
ECL1
23x47 23.47x47 G106
23x50 23.50x50 T109
TM3
3x28 3.28x28 R120
3x29 3.29x29 E121
3x33 3.33x33 F125
3x36 3.36x36 L128
3x37 3.37x37 S129
TM5
5x47 5.47x47 F210
TM6
6x48 6.48x48 W269
6x51 6.51x51 L272
6x55 6.55x55 L276
TM7
7x38 7.39x38 L297