Structure information

MRGPRX2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VV0

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-04077-Y

PUBLICATION DATE

Dec. 1, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PAMP-12 M109 3.32x32 TM3 hydrophobic
PAMP-12 E164 4.60x60 TM4 polar (charge-assisted hydrogen bond)
PAMP-12 C168 4.64x64 TM4 hydrophobic
PAMP-12 C168 4.64x64 TM4 Van der Waals
PAMP-12 G169 ECL2 Van der Waals
PAMP-12 F170 ECL2 Van der Waals
PAMP-12 F170 ECL2 hydrophobic
PAMP-12 C180 5.36x36 TM5 Van der Waals
PAMP-12 D184 5.40x40 TM5 polar (charge-assisted hydrogen bond)
PAMP-12 W243 6.55x55 TM6 polar (hydrogen bond with backbone)
PAMP-12 W243 6.55x55 TM6 Van der Waals
PAMP-12 L247 6.59x59 TM6 Van der Waals
PAMP-12 L247 6.59x59 TM6 hydrophobic
PAMP-12 W248 6.60x60 TM6 Van der Waals
PAMP-12 F257 7.31x30 TM7 hydrophobic
PAMP-12 F257 7.31x30 TM7 Van der Waals

Ligands

PAMP-12

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Residue Diagrams

G N G V L G V L A I F L I L F V P I L T 1 L S L A G A D F L F L C F Q I I N C L V 2 T S L M S L G A L Y A C T M V T T F F S 3 S A V V C V L L W A L S L L L S I L E G 4 S S G C L V M F L F I L W A A T I F D F 5 L L T V L V F L L C G L P F G I Q W F L 6 I P N A S S N L S S L V V S V P H I H 7
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ICL1 R R ICL1ECL1 I S I N F ECL1ICL2 P I W Y R C R R ICL2ECL2 G F L F S D G ECL2ICL3 S R G L ICL3ECL3 K D S D V ECL3N-term M D P T T P A W G T E S T T V N G N D Q A L L L L C G K E N-termC-term R K Q W R L Q Q P I L K L A L Q R A L Q D I A E V D H S E G C F R Q G T P E M S R S S L V C-term T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P R H L S A V V C V L L W A L S L L L S I L E G K F C D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX2
TM3
3x32 3.32x32 M109
TM4
4x60 4.60x60 E164
4x64 4.64x64 C168
TM5
5x36 5.36x36 C180
5x40 5.40x40 D184
TM6
6x55 6.55x55 W243
6x59 6.59x59 L247
6x60 6.60x60 W248
TM7
7x30 7.31x30 F257