Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WC9

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

PUBLICATION DATE

Jan. 26, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
IHCH-7086 D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
IHCH-7086 S159 3.36x36 TM3 Van der Waals
IHCH-7086 L228 45.51x51 ECL2 hydrophobic
IHCH-7086 L228 45.51x51 ECL2 Van der Waals
IHCH-7086 L229 45.52x52 ECL2 hydrophobic
IHCH-7086 L229 45.52x52 ECL2 Van der Waals
IHCH-7086 F243 5.47x47 TM5 Van der Waals
IHCH-7086 F243 5.47x47 TM5 aromatic (face-to-face)
IHCH-7086 F332 6.44x44 TM6 Van der Waals
IHCH-7086 W336 6.48x48 TM6 hydrophobic
IHCH-7086 W336 6.48x48 TM6 Van der Waals
IHCH-7086 F339 6.51x51 TM6 aromatic (edge-to-face)
IHCH-7086 F339 6.51x51 TM6 Van der Waals
IHCH-7086 F340 6.52x52 TM6 aromatic (edge-to-face)
IHCH-7086 F340 6.52x52 TM6 Van der Waals
IHCH-7086 N343 6.55x55 TM6 Van der Waals
IHCH-7086 L362 7.35x34 TM7 Van der Waals
IHCH-7086 L362 7.35x34 TM7 hydrophobic
IHCH-7086 V366 7.39x38 TM7 hydrophobic
IHCH-7086 Y370 7.43x42 TM7 Van der Waals

Ligands

IHCH-7086

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x32 3.32x32 D155
3x36 3.36x36 S159
ECL2
45x51 45.51x51 L228
45x52 45.52x52 L229
TM5
5x47 5.47x47 F243
TM6
6x44 6.44x44 F332
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
6x55 6.55x55 N343
TM7
7x34 7.35x34 L362
7x38 7.39x38 V366
7x42 7.43x42 Y370