Structure information

GPR119

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XZ6

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-022-00816-5

PUBLICATION DATE

Aug. 24, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
APD668 L61 2.60x60 TM2 polar (hydrogen bond)
APD668 Q65 2.64x64 TM2 polar (hydrogen bond)
APD668 M82 3.29x29 TM3 polar (hydrogen bond)
APD668 V85 3.32x32 TM3 polar (hydrogen bond with backbone)
APD668 V85 3.32x32 TM3 polar (hydrogen bond)
APD668 T86 3.33x33 TM3 polar (hydrogen bond)
APD668 T86 3.33x33 TM3 polar (hydrogen bond with backbone)
APD668 A89 3.36x36 TM3 polar (hydrogen bond)
APD668 A89 3.36x36 TM3 polar (hydrogen bond with backbone)
APD668 A90 3.37x37 TM3 polar (hydrogen bond with backbone)
APD668 A90 3.37x37 TM3 polar (hydrogen bond)
APD668 V93 3.40x40 TM3 polar (hydrogen bond)
APD668 L94 3.41x41 TM3 hydrophobic
APD668 L94 3.41x41 TM3 Van der Waals
APD668 I136 4.56x56 TM4 Van der Waals
APD668 I136 4.56x56 TM4 hydrophobic
APD668 S156 45.51x51 ECL2 polar (hydrogen bond)
APD668 F157 45.52x52 ECL2 polar (hydrogen bond)
APD668 F157 45.52x52 ECL2 polar (hydrogen bond with backbone)
APD668 L169 5.43x44 TM5 polar (hydrogen bond with backbone)
APD668 L169 5.43x44 TM5 polar (hydrogen bond)
APD668 G173 5.47x47 TM5 Van der Waals
APD668 F174 5.48x48 TM5 polar (hydrogen bond with backbone)
APD668 F174 5.48x48 TM5 polar (hydrogen bond)
APD668 W238 6.48x48 TM6 polar (hydrogen bond)
APD668 F241 6.51x51 TM6 polar (hydrogen bond)
APD668 L242 6.52x52 TM6 Van der Waals
APD668 L242 6.52x52 TM6 hydrophobic
APD668 E261 7.35x34 TM7 Van der Waals
APD668 E261 7.35x34 TM7 polar (hydrogen bond with backbone)
APD668 R262 7.36x35 TM7 polar (charge-assisted hydrogen bond)
APD668 W265 7.39x38 TM7 polar (hydrogen bond)
APD668 W265 7.39x38 TM7 polar (hydrogen bond)
APD668 W265 7.39x38 TM7 aromatic (face-to-face)

Ligands

APD668

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Residue Diagrams

T N T A I I L S A L V A L I V G F S F S 1 L N L A V A D T L I G V A I S G L L T D 2 L M V T L V S A A A S S T V F A M R L S 3 A G A C I A G L W L V S Y L I G F L P L 4 F F V F L L M A P F F G V C S L T L V F H 5 S V L I G S F A L S W T P F L I T G I V 6 L P N L L S N G V G L L W L Y R E L V 7
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ICL1 I H K N D ICL1ECL1 S P S ECL1ICL2 P F R Y L K I M ICL2ECL2 P M F Q Q T A Y K G Q C S F F A V ECL2ICL3 A M A G G Y ICL3ECL3 Q E C H L ECL3C-term G V K K V L T S F L L F L S A R N C G P E R P R E S S C H I V T I S S S E F D G C-term M E S S F S F G V I L A V L A S L I I A T N T L V A V A V L L L G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q S G F V A G A C I A G L W L V S Y L I G F L P L G I F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G R S P R T P S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E L Y H V R L Q M A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR119
TM2
2x60 2.60x60 L61
2x64 2.64x64 Q65
TM3
3x29 3.29x29 M82
3x32 3.32x32 V85
3x33 3.33x33 T86
3x36 3.36x36 A89
3x37 3.37x37 A90
3x40 3.40x40 V93
3x41 3.41x41 L94
TM4
4x56 4.56x56 I136
ECL2
45x51 45.51x51 S156
45x52 45.52x52 F157
TM5
5x44 5.43x44 L169
5x47 5.47x47 G173
5x48 5.48x48 F174
TM6
6x48 6.48x48 W238
6x51 6.51x51 F241
6x52 6.52x52 L242
TM7
7x34 7.35x34 E261
7x35 7.36x35 R262
7x38 7.39x38 W265