Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8CIC

SPECIES

Homo sapiens

RESOLUTION

2.100

PREFERRED CHAIN

A

REFERENCE

10.1038/S42004-023-00894-6

PUBLICATION DATE

May 31, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AB928 Y9 1.35x35 TM1 aromatic (face-to-edge)
AB928 A63 2.61x60 TM2 hydrophobic
AB928 V84 3.32x32 TM3 polar (hydrogen bond with backbone)
AB928 V84 3.32x32 TM3 Van der Waals
AB928 L85 3.33x33 TM3 hydrophobic
AB928 L85 3.33x33 TM3 Van der Waals
AB928 F168 45.52x52 ECL2 aromatic (face-to-face)
AB928 F168 45.52x52 ECL2 Van der Waals
AB928 E169 ECL2 polar (charge-assisted hydrogen bond)
AB928 M177 5.38x40 TM5 Van der Waals
AB928 M177 5.38x40 TM5 hydrophobic
AB928 W246 6.48x48 TM6 Van der Waals
AB928 W246 6.48x48 TM6 hydrophobic
AB928 L249 6.51x51 TM6 hydrophobic
AB928 L249 6.51x51 TM6 Van der Waals
AB928 H250 6.52x52 TM6 aromatic (face-to-edge)
AB928 H250 6.52x52 TM6 Van der Waals
AB928 N253 6.55x55 TM6 polar (hydrogen bond)
AB928 N253 6.55x55 TM6 polar (hydrogen bond)
AB928 L267 7.32x31 TM7 hydrophobic
AB928 Y271 7.36x35 TM7 aromatic (face-to-edge)
AB928 Y271 7.36x35 TM7 Van der Waals
AB928 I274 7.39x38 TM7 hydrophobic
AB928 I274 7.39x38 TM7 Van der Waals

Ligands

AB928

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM1
1x35 1.35x35 Y9
TM2
2x60 2.61x60 A63
TM3
3x32 3.32x32 V84
3x33 3.33x33 L85
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x31 7.32x31 L267
7x35 7.36x35 Y271
7x38 7.39x38 I274