Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8EFL

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2022.09.041

PUBLICATION DATE

Nov. 9, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4452384 W135 23.50x50 ECL1 hydrophobic
CHEMBL4452384 D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL4452384 Y150 3.33x33 TM3 Van der Waals
CHEMBL4452384 Y150 3.33x33 TM3 hydrophobic
CHEMBL4452384 M153 3.36x36 TM3 Van der Waals
CHEMBL4452384 M153 3.36x36 TM3 hydrophobic
CHEMBL4452384 C219 45.50x50 ECL2 Van der Waals
CHEMBL4452384 I298 6.51x51 TM6 hydrophobic
CHEMBL4452384 I298 6.51x51 TM6 Van der Waals
CHEMBL4452384 H299 6.52x52 TM6 Van der Waals
CHEMBL4452384 Y328 7.43x42 TM7 Van der Waals

Ligands

CHEMBL4452384

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
ECL1
23x50 23.50x50 W135
TM3
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
ECL2
45x50 45.50x50 C219
TM6
6x51 6.51x51 I298
6x52 6.52x52 H299
TM7
7x42 7.43x42 Y328