Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8F7R

SPECIES

Homo sapiens

RESOLUTION

3.280

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2022.12.026

PUBLICATION DATE

Dec. 14, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
endomorphin-1 N129 2.63x63 TM2 polar (hydrogen bond)
endomorphin-1 N129 2.63x63 TM2 polar (hydrogen bond)
endomorphin-1 Y130 2.64x64 TM2 Van der Waals
endomorphin-1 Y130 2.64x64 TM2 hydrophobic
endomorphin-1 W135 23.50x50 ECL1 Van der Waals
endomorphin-1 W135 23.50x50 ECL1 aromatic (face-to-edge)
endomorphin-1 V145 3.28x28 TM3 hydrophobic
endomorphin-1 V145 3.28x28 TM3 Van der Waals
endomorphin-1 I146 3.29x29 TM3 hydrophobic
endomorphin-1 I146 3.29x29 TM3 Van der Waals
endomorphin-1 D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
endomorphin-1 Y150 3.33x33 TM3 Van der Waals
endomorphin-1 Y150 3.33x33 TM3 hydrophobic
endomorphin-1 M153 3.36x36 TM3 hydrophobic
endomorphin-1 M153 3.36x36 TM3 Van der Waals
endomorphin-1 C219 45.50x50 ECL2 polar (hydrogen bond with backbone)
endomorphin-1 C219 45.50x50 ECL2 Van der Waals
endomorphin-1 V238 5.42x43 TM5 Van der Waals
endomorphin-1 V238 5.42x43 TM5 hydrophobic
endomorphin-1 V302 6.55x55 TM6 hydrophobic
endomorphin-1 W320 7.35x34 TM7 hydrophobic
endomorphin-1 W320 7.35x34 TM7 Van der Waals
endomorphin-1 H321 7.36x35 TM7 Van der Waals
endomorphin-1 H321 7.36x35 TM7 aromatic (edge-to-face)
endomorphin-1 I324 7.39x38 TM7 hydrophobic
endomorphin-1 I324 7.39x38 TM7 Van der Waals
endomorphin-1 Y328 7.43x42 TM7 Van der Waals
endomorphin-1 Y328 7.43x42 TM7 polar (hydrogen bond)

Ligands

endomorphin-1

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x63 2.63x63 N129
2x64 2.64x64 Y130
ECL1
23x50 23.50x50 W135
TM3
3x28 3.28x28 V145
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
ECL2
45x50 45.50x50 C219
TM5
5x43 5.42x43 V238
TM6
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x35 7.36x35 H321
7x38 7.39x38 I324
7x42 7.43x42 Y328