Structure information

κ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8F7W

SPECIES

Homo sapiens

RESOLUTION

3.190

PREFERRED CHAIN

R

PUBLICATION DATE

Dec. 14, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
dynorphin A-(1-8) Q115 2.60x60 TM2 polar (hydrogen bond)
dynorphin A-(1-8) V134 3.28x28 TM3 Van der Waals
dynorphin A-(1-8) V134 3.28x28 TM3 hydrophobic
dynorphin A-(1-8) I135 3.29x29 TM3 hydrophobic
dynorphin A-(1-8) I135 3.29x29 TM3 Van der Waals
dynorphin A-(1-8) D138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
dynorphin A-(1-8) Y139 3.33x33 TM3 Van der Waals
dynorphin A-(1-8) Y139 3.33x33 TM3 aromatic (face-to-edge)
dynorphin A-(1-8) M142 3.36x36 TM3 Van der Waals
dynorphin A-(1-8) M142 3.36x36 TM3 hydrophobic
dynorphin A-(1-8) K200 ECL2 polar (charge-assisted hydrogen bond)
dynorphin A-(1-8) E209 ECL2 Van der Waals
dynorphin A-(1-8) C210 45.50x50 ECL2 Van der Waals
dynorphin A-(1-8) Y219 5.31x32 TM5 Van der Waals
dynorphin A-(1-8) Y219 5.31x32 TM5 polar (hydrogen bond)
dynorphin A-(1-8) V230 5.42x43 TM5 Van der Waals
dynorphin A-(1-8) I294 6.55x55 TM6 Van der Waals
dynorphin A-(1-8) I294 6.55x55 TM6 hydrophobic
dynorphin A-(1-8) E297 6.58x58 TM6 polar (charge-assisted hydrogen bond)
dynorphin A-(1-8) H304 ECL3 Van der Waals
dynorphin A-(1-8) A308 7.31x30 TM7 Van der Waals
dynorphin A-(1-8) L309 7.32x31 TM7 Van der Waals
dynorphin A-(1-8) Y312 7.35x34 TM7 polar (hydrogen bond)
dynorphin A-(1-8) Y312 7.35x34 TM7 Van der Waals
dynorphin A-(1-8) I316 7.39x38 TM7 hydrophobic
dynorphin A-(1-8) I316 7.39x38 TM7 Van der Waals
dynorphin A-(1-8) Y320 7.43x42 TM7 polar (hydrogen bond)
dynorphin A-(1-8) Y320 7.43x42 TM7 Van der Waals

Ligands

dynorphin A-(1-8)

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Residue Diagrams

S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7
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ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
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Residue Table


GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x60 2.60x60 Q115
TM3
3x28 3.28x28 V134
3x29 3.29x29 I135
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
ECL2
45x50 45.50x50 C210
TM5
5x32 5.31x32 Y219
5x43 5.42x43 V230
TM6
6x55 6.55x55 I294
6x58 6.58x58 E297
TM7
7x30 7.31x30 A308
7x31 7.32x31 L309
7x34 7.35x34 Y312
7x38 7.39x38 I316
7x42 7.43x42 Y320