PDB
8H0Q
Resolution
3.3 Å
Released
Aug. 9, 2023
Receptor
BB2
Class
A
Species
Homo sapiens
Ligand
GRP(14-27)
Function
Agonist
Reference
10.1038/S41422-022-00743-6

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
GRP(14-27) R100 2.64x63 TM2 polar (charge-assisted hydrogen bond)
GRP(14-27) Y101 2.65x64 TM2 hydrophobic
GRP(14-27) Y101 2.65x64 TM2 Van der Waals
GRP(14-27) D104 ECL1 polar (hydrogen bond with backbone)
GRP(14-27) D104 ECL1 Van der Waals
GRP(14-27) R105 23.49x49 ECL1 Van der Waals
GRP(14-27) W106 23.50x50 ECL1 hydrophobic
GRP(14-27) W106 23.50x50 ECL1 Van der Waals
GRP(14-27) P117 3.29x29 TM3 Van der Waals
GRP(14-27) P117 3.29x29 TM3 hydrophobic
GRP(14-27) V124 3.36x36 TM3 hydrophobic
GRP(14-27) F193 ECL2 hydrophobic
GRP(14-27) F193 ECL2 Van der Waals
GRP(14-27) S195 ECL2 Van der Waals
GRP(14-27) S195 ECL2 polar (hydrogen bond)
GRP(14-27) P198 45.52x52 ECL2 Van der Waals
GRP(14-27) P198 45.52x52 ECL2 hydrophobic
GRP(14-27) W277 6.48x48 TM6 Van der Waals
GRP(14-27) N280 6.51x51 TM6 Van der Waals
GRP(14-27) N280 6.51x51 TM6 polar (hydrogen bond)
GRP(14-27) Y284 6.55x55 TM6 Van der Waals
GRP(14-27) Y284 6.55x55 TM6 hydrophobic
GRP(14-27) R287 6.58x58 TM6 polar (charge-assisted hydrogen bond)
GRP(14-27) T296 ECL3 Van der Waals
GRP(14-27) T296 ECL3 polar (hydrogen bond)
GRP(14-27) H300 7.31x30 TM7 Van der Waals
GRP(14-27) F301 7.32x31 TM7 hydrophobic
GRP(14-27) F301 7.32x31 TM7 Van der Waals
GRP(14-27) R308 7.39x38 TM7 polar (charge-assisted hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K S M R ICL1ECL1 D R W L F ECL1ICL2 P M D I Q A S H ICL2ECL2 D L H P F H E E S T N Q T F I S C A P Y P H S ECL2ICL3 P V E G ICL3ECL3 Y S E V D T ECL3N-term M A L N D C F L L N L E V D H F M H C N I S S H S A D L P V N D D W S H N-termC-term C Q P G L I I R S H S T G R S T T C M T S L K S T N P S V A T F S L I N G N I C H E R Y V C-term P G I L Y V I P A V Y G V I I L I G L I G N I T L I K I F C T V N V P N L F I S S L A L G D L L L L I T C A P V D A S R Y L A G R I G C K L I P F I Q L T S V G V S V F T L T A L S A D R Y K A I V R A L M K I C L K A A F I W I I S M L L A I P E A V F S N E L H P K I H S M A S F L V F Y V I P L S I I S V Y Y Y F I A K N L I Q S A Y N L N I H V K K Q I E S R K R L A K T V L V F V G L F A F C W L P N H V I Y L Y R S Y H S M L H F V T S I C A R L L A F T N S C V N P F A L Y L L S K S F N T F R K Q Q L L C
Helix box plot — Download: PNG | SVG I N G I L G I L I I V G Y V A P I V Y L 1 S S L A L G D L L L L T I C A P V D A S R 2 A T L T F V S V G V S T L Q I F P I L K 3 I C L K A A F I W I I S M L L A I P E 4 Y Y V S I I S L P I V Y F V L F S A M S H 5 L V F V G L F A F C W L P N H V I Y L Y 6 F P N V C S N T F A L L R A C I S T V 7

GPCRdb(A)
GPCRdb(A)
BB2 receptor
TM2
2x63 2.64x63 R100
2x64 2.65x64 Y101
ECL1
23x49 23.49x49 R105
23x50 23.50x50 W106
TM3
3x29 3.29x29 P117
3x36 3.36x36 V124
ECL2
45x52 45.52x52 P198
TM6
6x48 6.48x48 W277
6x51 6.51x51 N280
6x55 6.55x55 Y284
6x58 6.58x58 R287
TM7
7x30 7.31x30 H300
7x31 7.32x31 F301
7x38 7.39x38 R308