Structure information

A2B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8HDO

SPECIES

Homo sapiens

RESOLUTION

2.870

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-022-00503-1

PUBLICATION DATE

Jan. 18, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
BAY 60-6583 A64 2.61x60 TM2 Van der Waals
BAY 60-6583 A64 2.61x60 TM2 polar (hydrogen bond with backbone)
BAY 60-6583 I67 2.64x63 TM2 hydrophobic
BAY 60-6583 I67 2.64x63 TM2 Van der Waals
BAY 60-6583 S68 2.65x64 TM2 Van der Waals
BAY 60-6583 V85 3.32x32 TM3 Van der Waals
BAY 60-6583 L86 3.33x33 TM3 Van der Waals
BAY 60-6583 T89 3.36x36 TM3 polar (hydrogen bond)
BAY 60-6583 F173 45.52x52 ECL2 hydrophobic
BAY 60-6583 F173 45.52x52 ECL2 Van der Waals
BAY 60-6583 M179 5.35x37 TM5 Van der Waals
BAY 60-6583 M182 5.38x40 TM5 Van der Waals
BAY 60-6583 M182 5.38x40 TM5 hydrophobic
BAY 60-6583 N186 5.42x43 TM5 Van der Waals
BAY 60-6583 W247 6.48x48 TM6 hydrophobic
BAY 60-6583 W247 6.48x48 TM6 Van der Waals
BAY 60-6583 H251 6.52x52 TM6 polar (hydrogen bond)
BAY 60-6583 H251 6.52x52 TM6 Van der Waals
BAY 60-6583 N254 6.55x55 TM6 polar (hydrogen bond)
BAY 60-6583 M272 7.35x34 TM7 hydrophobic
BAY 60-6583 M272 7.35x34 TM7 Van der Waals
BAY 60-6583 I276 7.39x38 TM7 hydrophobic
BAY 60-6583 I276 7.39x38 TM7 Van der Waals
BAY 60-6583 H280 7.43x42 TM7 Van der Waals

Ligands

BAY 60-6583

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Residue Diagrams

V N G A V S L A A I V L E L A V Y L A D 1 V S L A A A D V A V G F L A I P F A I T I 2 A L L S F I S S Q T L V L V F C A L F L 3 A R G V I A V L W V L A F G I G L T P F 4 Y I V L M I L L P P L V C G F F N F Y V M Y 5 A M I V G I F A L C W L P V H A V N C V 6 I P N V V S N A H S L L I A M N M A W 7
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ICL1 N T L Q ICL1ECL1 F C T ECL1ICL2 P L R Y K S L V ICL2ECL2 W N S K D S A T N N C T E P W D G T T N E S C C L V K C L F E N V V ECL2ICL3 L M D ICL3ECL3 P A Q G K N K ECL3N-term M L L N-termC-term S G N G Q A G V Q P A L G V G L C-term E T Q D A L Y V A L E L V I A A L S V A G N V L V C A A V G T A T P T N Y F L V S L A A A D V A V G L F A I P F A I T I S L G D F Y G C L F L A C F V L V L T Q S S I F S L L A V A V D R Y L A I C V T G T R A R G V I A V L W V L A F G I G L T P F L G P M S Y M V Y F N F F G C V L P P L L I M L V I Y I K I F L V A C R Q L Q R T E H S R T T L Q R E I H A A K S L A M I V G I F A L C W L P V H A V N C V T L F Q P K W A M N M A I L L S H A N S V V N P I V Y A Y R N R D F H K Y L L V K F R Y T I I S R C Q A D
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2B receptor
TM2
2x60 2.61x60 A64
2x63 2.64x63 I67
2x64 2.65x64 S68
TM3
3x32 3.32x32 V85
3x33 3.33x33 L86
3x36 3.36x36 T89
ECL2
45x52 45.52x52 F173
TM5
5x37 5.35x37 M179
5x40 5.38x40 M182
5x43 5.42x43 N186
TM6
6x48 6.48x48 W247
6x52 6.52x52 H251
6x55 6.55x55 N254
TM7
7x34 7.35x34 M272
7x38 7.39x38 I276
7x42 7.43x42 H280