Structure information

NK3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JBG

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

B

REFERENCE

PUBLICATION DATE

Feb. 7, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
neurokinin B Q77 N-term polar (hydrogen bond)
neurokinin B Q77 N-term Van der Waals
neurokinin B F78 N-term aromatic (face-to-edge)
neurokinin B F78 N-term Van der Waals
neurokinin B N138 2.57x57 TM2 Van der Waals
neurokinin B N138 2.57x57 TM2 polar (hydrogen bond)
neurokinin B N142 2.61x61 TM2 Van der Waals
neurokinin B N142 2.61x61 TM2 polar (hydrogen bond)
neurokinin B Y145 2.64x64 TM2 hydrophobic
neurokinin B Y145 2.64x64 TM2 Van der Waals
neurokinin B A146 2.65x65 TM2 hydrophobic
neurokinin B A146 2.65x65 TM2 Van der Waals
neurokinin B N162 3.29x29 TM3 Van der Waals
neurokinin B I166 3.33x33 TM3 Van der Waals
neurokinin B Q218 4.60x61 TM4 Van der Waals
neurokinin B C233 45.50x50 ECL2 hydrophobic
neurokinin B C233 45.50x50 ECL2 Van der Waals
neurokinin B F234 45.51x51 ECL2 hydrophobic
neurokinin B F234 45.51x51 ECL2 Van der Waals
neurokinin B H248 5.39x40 TM5 Van der Waals
neurokinin B Y315 6.51x51 TM6 Van der Waals
neurokinin B Y318 6.54x54 TM6 Van der Waals
neurokinin B F319 6.55x55 TM6 hydrophobic
neurokinin B F319 6.55x55 TM6 Van der Waals
neurokinin B N329 ECL3 polar (hydrogen bond)
neurokinin B N329 ECL3 Van der Waals
neurokinin B R330 ECL3 Van der Waals
neurokinin B I334 7.31x30 TM7 Van der Waals
neurokinin B Q335 7.32x31 TM7 Van der Waals
neurokinin B Y338 7.35x34 TM7 polar (hydrogen bond)
neurokinin B Y338 7.35x34 TM7 Van der Waals
neurokinin B F342 7.39x38 TM7 Van der Waals

Ligands

neurokinin B

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Residue Diagrams

L N G L V A V A V V V G Y A L S W L A I 1 V N L A F S D A S M A A F N T L V N F I 2 A T M S Y I S A F V A T I P F F N Q F R 3 T K I V I G S I W I L A F L L A F P Q 4 Y T I G M I L L P F C Y V L I I V I I H Y 5 I I V V M T F A I C W L P Y H I Y F I L 6 I P N Y M T S S M A L W F S A L Y V Q 7
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ICL1 K R M R ICL1ECL1 E W Y F ECL1ICL2 P L K P R L ICL2ECL2 K T K V M P G R T L C F V Q W P E ECL2ICL3 T C D ICL3ECL3 Q Q L N R W ECL3N-term M A T L P A A E T W I D G G G G V G A D A V N L T A S L A A G A A T G A V E T G W L Q L L D Q A G N L S S S P S A L G L P V A S P A P S Q P W A N L T N Q F V Q N-termC-term R W C P F I K V S S Y D E L E L K T T R F H P N R Q S S M Y T V T R M E S M T V V F D P N D A D T T R S S R K K R A T P R D P S F N G C S R R N S K S A S A T S S F I S S P Y T S V D E Y S C-term P S W R I A L W S L A Y G V V V A V A V L G N L I V I W I I L A H T V T N Y F L V N L A F S D A S M A A F N T L V N F I Y A L H S G A N Y C R F Q N F F P I T A V F A S I Y S M T A I A V D R Y M A I I D S A T A T K I V I G S I W I L A F L L A F P Q C L Y S G P K Q H F T Y H I I V I I L V Y C F P L L I M G I T Y T I V G I T L W G G E I P G D K Y H E Q L K A K R K V V K M M I I V V M T F A I C W L P Y H I Y F I L T A I Y K Y I Q Q V Y L A S F W L A M S S T M Y N P I I Y C C L N K R F K R F R A G A F
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Residue Table


GPCRdb(A)
GPCRdb(A)
NK3 receptor
TM2
2x57 2.57x57 N138
2x61 2.61x61 N142
2x64 2.64x64 Y145
2x65 2.65x65 A146
TM3
3x29 3.29x29 N162
3x33 3.33x33 I166
TM4
4x61 4.60x61 Q218
ECL2
45x50 45.50x50 C233
45x51 45.51x51 F234
TM5
5x40 5.39x40 H248
TM6
6x51 6.51x51 Y315
6x54 6.54x54 Y318
6x55 6.55x55 F319
TM7
7x30 7.31x30 I334
7x31 7.32x31 Q335
7x34 7.35x34 Y338
7x38 7.39x38 F342