Structure information

TA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JLQ

SPECIES

Homo sapiens

RESOLUTION

2.840

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-023-06804-Z

PUBLICATION DATE

Nov. 15, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
fenoldopam R83 2.64x63 TM2 polar (charge-assisted hydrogen bond)
fenoldopam T100 3.29x29 TM3 Van der Waals
fenoldopam D103 3.32x32 TM3 Van der Waals
fenoldopam I104 3.33x33 TM3 hydrophobic
fenoldopam I104 3.33x33 TM3 Van der Waals
fenoldopam S107 3.36x36 TM3 Van der Waals
fenoldopam C182 45.50x50 ECL2 polar (hydrogen bond with backbone)
fenoldopam C182 45.50x50 ECL2 Van der Waals
fenoldopam S183 45.51x51 ECL2 Van der Waals
fenoldopam V184 45.52x52 ECL2 Van der Waals
fenoldopam V184 45.52x52 ECL2 polar (hydrogen bond with backbone)
fenoldopam F186 ECL2 Van der Waals
fenoldopam F186 ECL2 hydrophobic
fenoldopam T194 5.42x43 TM5 polar (hydrogen bond)
fenoldopam W264 6.48x48 TM6 hydrophobic
fenoldopam W264 6.48x48 TM6 Van der Waals
fenoldopam F267 6.51x51 TM6 Van der Waals
fenoldopam F267 6.51x51 TM6 aromatic (edge-to-face)
fenoldopam F268 6.52x52 TM6 hydrophobic
fenoldopam F268 6.52x52 TM6 Van der Waals
fenoldopam I290 7.39x38 TM7 hydrophobic
fenoldopam I290 7.39x38 TM7 Van der Waals

Ligands

fenoldopam

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Residue Diagrams

L N G V L T T L I I L V M L S Y L S A R 1 H S M A T V D F L L G L C V M P Y S M V R 2 F S L H F I S A S S L M I D T S T H I K 3 I C V M I F I S W S V P A V F A F G M I 4 Y V C L M I S G P I Y F S T M F T L V G S 5 G I V M G V F L I C W C P F F I C T V M 6 M P N F T S N L Y G F W I L V D N L T 7
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ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
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Residue Table


GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM2
2x63 2.64x63 R83
TM3
3x29 3.29x29 T100
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
ECL2
45x50 45.50x50 C182
45x51 45.51x51 S183
45x52 45.52x52 V184
TM5
5x43 5.42x43 T194
TM6
6x48 6.48x48 W264
6x51 6.51x51 F267
6x52 6.52x52 F268
TM7
7x38 7.39x38 I290