Structure information

GPR6

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8T1W

SPECIES

Homo sapiens

RESOLUTION

3.490

PREFERRED CHAIN

A

REFERENCE

10.1126/SCISIGNAL.ADO8741

PUBLICATION DATE

Dec. 4, 2024
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
CVN424 H128 2.60x60 TM2 polar (hydrogen bond)
CVN424 V145 3.29x29 TM3 Van der Waals
CVN424 V145 3.29x29 TM3 hydrophobic
CVN424 L148 3.32x32 TM3 hydrophobic
CVN424 L148 3.32x32 TM3 Van der Waals
CVN424 V149 3.33x33 TM3 Van der Waals
CVN424 V149 3.33x33 TM3 hydrophobic
CVN424 F152 3.36x36 TM3 Van der Waals
CVN424 F152 3.36x36 TM3 aromatic (face-to-face)
CVN424 V219 ECL2 hydrophobic
CVN424 V219 ECL2 Van der Waals
CVN424 L222 ECL2 Van der Waals
CVN424 V227 5.40x40 TM5 Van der Waals
CVN424 V227 5.40x40 TM5 hydrophobic
CVN424 L230 5.43x43 TM5 hydrophobic
CVN424 L230 5.43x43 TM5 Van der Waals
CVN424 S231 5.44x44 TM5 Van der Waals
CVN424 S231 5.44x44 TM5 polar (hydrogen bond)
CVN424 W292 6.48x48 TM6 Van der Waals
CVN424 W292 6.48x48 TM6 hydrophobic
CVN424 F295 6.51x51 TM6 aromatic (edge-to-face)
CVN424 F295 6.51x51 TM6 Van der Waals
CVN424 A296 6.52x52 TM6 Van der Waals
CVN424 A296 6.52x52 TM6 polar (hydrogen bond with backbone)
CVN424 C299 6.55x55 TM6 Van der Waals
CVN424 L315 7.39x38 TM7 hydrophobic
CVN424 L315 7.39x38 TM7 Van der Waals
CVN424 T319 7.43x42 TM7 polar (hydrogen bond)
CVN424 T319 7.43x42 TM7 Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 29 of 29 entries

Ligands

CVN424

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Residue Diagrams

A N E G A I V T G S V C L L V D W P N V 1 G S L A T A D L L A G C G L I L H F V F 2 A L L S S V S A A F S A V L F G V T L L 3 V H L L L A A T W T V S L G L G L L P V 4 Y L H L M I G F V M F F A A S L L A V H 5 A V V L G T F G A S W L P F A I Y C V V 6 I P N I M S N Y T A P L L T A Y T Y V 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term A V N P W D V L L C V S G T V I A G E N A L V V A L I A S T T P M F V L V G S L A T A D L L A G C G L I L H F V F Q Y S E T V S L L T V G F L V A S F A A S V S S L L A I T V D R Y L S L Y N S R R T L L G V H L L L A A T W T V S L G L G L L P V L G A R S H V A L L S A A F F M V F G I M L H L Y V R I C Q V V W R H A H Q I A L A P P H L A A T R K G V G T L A V V L G T F G A S W L P F A I Y C V V G A V Y T Y A T L L P A T Y N S M I N P I I Y A F R N Q E L W L I Q R A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR6
TM2
2x60 2.60x60 H128
TM3
3x29 3.29x29 V145
3x32 3.32x32 L148
3x33 3.33x33 V149
3x36 3.36x36 F152
TM5
5x40 5.40x40 V227
5x43 5.43x43 L230
5x44 5.44x44 S231
TM6
6x48 6.48x48 W292
6x51 6.51x51 F295
6x52 6.52x52 A296
6x55 6.55x55 C299
TM7
7x38 7.39x38 L315
7x42 7.43x42 T319