Structure information

mGlu3 receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

8TR2

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

A

REFERENCE

10.1101/2023.08.13.552748

PUBLICATION DATE

July 31, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid R64 N-term polar (charge-assisted hydrogen bond)
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid R68 N-term polar (charge-assisted hydrogen bond)
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid S149 N-term polar (hydrogen bond with backbone)
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid S149 N-term Van der Waals
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid Y150 N-term Van der Waals
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid S151 N-term polar (hydrogen bond with backbone)
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid S151 N-term Van der Waals
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid A172 N-term Van der Waals
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid S173 N-term Van der Waals
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid T174 N-term polar (hydrogen bond with backbone)
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid T174 N-term polar (hydrogen bond)
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid T174 N-term Van der Waals
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid Y222 N-term hydrophobic
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid Y222 N-term Van der Waals
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid D301 N-term polar (charge-assisted hydrogen bond)
(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid K389 N-term polar (charge-assisted hydrogen bond)

Ligands

(1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid

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Residue Diagrams

C T C M F G L C A I T V P G I A W 1 Y I L L F G V G L S Y C M T F F F I 2 T L L A S Y C I A F S S G L G L R R L A 3 Q V F I C L G L I L V Q I V M V S V W L 4 A Y V T C L I V L I V D Y T L S I L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V F G S L S V S I C M T T T Q V R 7
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ICL1 T N N P L V K A S ICL1ECL1 A K P ECL1ICL2 D G V K N G A Q R P K F I ICL2ECL2 A P G T R R Y T L A E K R E T V I L K C N V ECL2ICL3 R K C P E N F N ICL3ECL3 S S D Y ECL3N-term M K M L T R L Q V L T L A L F S K G F L L S L G D H N F L R R E I K I E G D L V L G G L F P I N E K G T G T E E C G R I N E D R G I Q R L E A M L F A I D E I N K D D Y L L P G V K L G V H I L D T C S R D T Y A L E Q S L E F V R A S L T K V D E A E Y M C P D G S Y A I Q E N I P L L I A G V I G G S Y S S V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F Y Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E Q E A R L R N I C I A T A E K V G R S N I R K S Y D S V I R E L L Q K P N A R V V V L F M R S D D S R E L I A A A S R A N A S F T W V A S D G W G A Q E S I I K G S E H V A Y G A I T L E L A S Q P V R Q F D R Y F Q S L N P Y N N H R N P W F R D F W E Q K F Q C S L Q N K R N H R R V C D K H L A I D S S N Y E Q E S K I M F V V N A V Y A M A H A L H K M Q R T L C P N T T K L C D A M K I L D G K K L Y K D Y L L K I N F T A P F N P N K D A D S I V K F D T F G D G M G R Y N V F N F Q N V G G K Y S Y L K V G H W A E T L S L D V N S I H W S R N S V P T S Q C S D P C A P N E M K N M Q P G D V C C W I C I P C E P Y E Y L A D E F T C M D C G S G Q W P T A D L T G C Y D L P E D Y I R W E D A N-termC-term N R F S V S G T G T T Y S Q S S A S T Y V P T V C N G R E V L D S T T S S L C-term W A I G P V T I A C L G F M C T C M V V T V F I K H G R E L C Y I L L F G V G L S Y C M T F F F I S P V I C A L R R L G L G S S F A I C Y S A L L T K T N C I A R I F S P S S Q V F I C L G L I L V Q I V M V S V W L I L E K D S S M L I S L T Y D V I L V I L C T V Y A F K T E A K F I G F T M Y T T C I I W L A F L P I F Y V T R V Q T T T M C I S V S L S G F V V L G C L F A P K V H I I L F Q P Q K H R L N V V T H L
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Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu3 receptor