Structure information

IP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8X79

SPECIES

Homo sapiens

RESOLUTION

2.410

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADK5184

PUBLICATION DATE

March 6, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MRE-269 S20 1.39x39 TM1 polar (hydrogen bond with backbone)
MRE-269 S20 1.39x39 TM1 polar (hydrogen bond)
MRE-269 M23 1.42x42 TM1 Van der Waals
MRE-269 G63 2.53x53 TM2 Van der Waals
MRE-269 T64 2.54x54 TM2 Van der Waals
MRE-269 L67 2.57x57 TM2 polar (hydrogen bond with backbone)
MRE-269 L67 2.57x57 TM2 polar (hydrogen bond)
MRE-269 S68 2.58x58 TM2 polar (hydrogen bond)
MRE-269 S68 2.58x58 TM2 polar (hydrogen bond with backbone)
MRE-269 V71 2.61x61 TM2 polar (hydrogen bond)
MRE-269 Y75 2.65x65 TM2 polar (hydrogen bond)
MRE-269 Y75 2.65x65 TM2 polar (hydrogen bond)
MRE-269 M99 3.32x32 TM3 polar (hydrogen bond)
MRE-269 M99 3.32x32 TM3 polar (hydrogen bond with backbone)
MRE-269 F102 3.35x35 TM3 Van der Waals
MRE-269 F102 3.35x35 TM3 polar (hydrogen bond with backbone)
MRE-269 G103 3.36x36 TM3 Van der Waals
MRE-269 S106 3.39x39 TM3 polar (hydrogen bond)
MRE-269 P166 ECL2 Van der Waals
MRE-269 S168 ECL2 polar (hydrogen bond)
MRE-269 S168 ECL2 polar (hydrogen bond)
MRE-269 W169 ECL2 polar (hydrogen bond)
MRE-269 L255 6.51x51 TM6 Van der Waals
MRE-269 L275 7.36x35 TM7 polar (hydrogen bond)
MRE-269 F278 7.39x38 TM7 Van der Waals
MRE-269 F278 7.39x38 TM7 polar (hydrogen bond with backbone)
MRE-269 R279 7.40x39 TM7 polar (charge-assisted hydrogen bond)
MRE-269 Y281 7.42x41 TM7 polar (hydrogen bond with backbone)
MRE-269 Y281 7.42x41 TM7 Van der Waals
MRE-269 A282 7.43x42 TM7 polar (hydrogen bond)
MRE-269 A282 7.43x42 TM7 polar (hydrogen bond with backbone)
MRE-269 P285 7.46x46 TM7 Van der Waals
MRE-269 P285 7.46x46 TM7 hydrophobic

Ligands

MRE-269

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Residue Diagrams

G N G V V G A V F M L T S T A P 1 T G L A A T D L L G T S F L S P A V F V 2 A F L I L M S A L G F F T M A F A F A D 3 A R L A L P A I Y A F C V L F C A L P L 4 S G N C L F I A A V L L A V L G A Y A L 5 A L M T V V M A V C S L P L T I R C F T 6 W P D L I P N F A Y F R F A L L D 7
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ICL1 R P A R P ICL1ECL1 S S L L G L A R G G ECL1ICL2 P Y L Y A Q L D ICL2ECL2 L G Q H Q Q Y C P G S W C F L R M R W A ECL2ICL3 G S L G P R P R T G E ICL3ECL3 P D S S S E M G ECL3N-term M A D S C R N L T Y V R G S V G N-termC-term P A H G D S Q T P L S Q L A S G R R D P R A P S A P V G K E G S C V P L S A W G E G Q V E P L P P T Q Q S S G S A V G T S S K A E A S V A C S L C C-term P A T S T L M F V A G V V G N G L A L G I L S A R S A F A V L V T G L A A T D L L G T S F L S P A V F V A Y A R N P A L C D A F A F A M T F F G L A S M L I L F A M A V E R C L A L S H G P R C A R L A L P A I Y A F C V L F C A L P L L G Q P G G A A F S L A Y A G L V A L L V A A I F L C N G S V T L S L C R M Y R Q Q K R H Q D E V D H L I L L A L M T V V M A V C S L P L T I R C F T Q A V A D L L A F R F Y A F N P I L D P W V F I L F R K A L K L L C L V F Q R W V C C G
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Residue Table


GPCRdb(A)
GPCRdb(A)
IP receptor
TM1
1x39 1.39x39 S20
1x42 1.42x42 M23
TM2
2x53 2.53x53 G63
2x54 2.54x54 T64
2x57 2.57x57 L67
2x58 2.58x58 S68
2x61 2.61x61 V71
2x65 2.65x65 Y75
TM3
3x32 3.32x32 M99
3x35 3.35x35 F102
3x36 3.36x36 G103
3x39 3.39x39 S106
TM6
6x51 6.51x51 L255
TM7
7x35 7.36x35 L275
7x38 7.39x38 F278
7x39 7.40x39 R279
7x41 7.42x41 Y281
7x42 7.43x42 A282
7x46 7.46x46 P285