Structure information

SST5 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8X8N

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

June 12, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Octreotide Y89 2.53x53 TM2 polar (charge-assisted hydrogen bond)
Octreotide Y89 2.53x53 TM2 polar (hydrogen bond)
Octreotide L96 2.60x60 TM2 polar (hydrogen bond)
Octreotide N100 2.64x64 TM2 polar (hydrogen bond)
Octreotide N100 2.64x64 TM2 polar (hydrogen bond)
Octreotide D119 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Octreotide Q123 3.36x36 TM3 polar (hydrogen bond)
Octreotide N187 45.51x51 ECL2 polar (hydrogen bond)
Octreotide W190 ECL2 hydrophobic
Octreotide W190 ECL2 Van der Waals
Octreotide G198 5.35x36 TM5 polar (hydrogen bond with backbone)
Octreotide G198 5.35x36 TM5 Van der Waals
Octreotide F201 5.38x39 TM5 hydrophobic
Octreotide F201 5.38x39 TM5 Van der Waals
Octreotide I202 5.39x40 TM5 Van der Waals
Octreotide I202 5.39x40 TM5 hydrophobic
Octreotide F264 6.51x51 TM6 hydrophobic
Octreotide F264 6.51x51 TM6 Van der Waals
Octreotide P277 ECL3 Van der Waals
Octreotide Q278 ECL3 Van der Waals
Octreotide S282 7.31x30 TM7 polar (hydrogen bond)
Octreotide A283 7.32x31 TM7 Van der Waals
Octreotide Y286 7.35x34 TM7 polar (hydrogen bond)
Octreotide V290 7.39x38 TM7 polar (hydrogen bond)

Ligands

Octreotide

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Residue Diagrams

T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7
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ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM2
2x53 2.53x53 Y89
2x60 2.60x60 L96
2x64 2.64x64 N100
TM3
3x32 3.32x32 D119
3x36 3.36x36 Q123
ECL2
45x51 45.51x51 N187
TM5
5x36 5.35x36 G198
5x39 5.38x39 F201
5x40 5.39x40 I202
TM6
6x51 6.51x51 F264
TM7
7x30 7.31x30 S282
7x31 7.32x31 A283
7x34 7.35x34 Y286
7x38 7.39x38 V290