Structure information

GPR119

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZR5

SPECIES

Homo sapiens

RESOLUTION

3.310

PREFERRED CHAIN

C

REFERENCE

PUBLICATION DATE

June 19, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
DS-8500a F7 1.35x35 TM1 polar (hydrogen bond)
DS-8500a L61 2.60x60 TM2 Van der Waals
DS-8500a V85 3.32x32 TM3 polar (hydrogen bond)
DS-8500a T86 3.33x33 TM3 polar (hydrogen bond with backbone)
DS-8500a T86 3.33x33 TM3 polar (hydrogen bond)
DS-8500a A89 3.36x36 TM3 polar (hydrogen bond)
DS-8500a A90 3.37x37 TM3 polar (hydrogen bond with backbone)
DS-8500a A90 3.37x37 TM3 Van der Waals
DS-8500a V93 3.40x40 TM3 polar (hydrogen bond)
DS-8500a L94 3.41x41 TM3 Van der Waals
DS-8500a L94 3.41x41 TM3 hydrophobic
DS-8500a I136 4.56x56 TM4 Van der Waals
DS-8500a C155 45.50x50 ECL2 Van der Waals
DS-8500a C155 45.50x50 ECL2 polar (hydrogen bond with backbone)
DS-8500a S156 45.51x51 ECL2 polar (hydrogen bond)
DS-8500a F157 45.52x52 ECL2 polar (hydrogen bond with backbone)
DS-8500a F157 45.52x52 ECL2 polar (hydrogen bond)
DS-8500a V166 5.40x41 TM5 Van der Waals
DS-8500a L169 5.43x44 TM5 hydrophobic
DS-8500a L169 5.43x44 TM5 Van der Waals
DS-8500a G173 5.47x47 TM5 Van der Waals
DS-8500a F174 5.48x48 TM5 polar (hydrogen bond with backbone)
DS-8500a F174 5.48x48 TM5 polar (hydrogen bond)
DS-8500a W238 6.48x48 TM6 aromatic (face-to-face)
DS-8500a W238 6.48x48 TM6 polar (hydrogen bond)
DS-8500a F241 6.51x51 TM6 aromatic (face-to-edge)
DS-8500a F241 6.51x51 TM6 polar (hydrogen bond)
DS-8500a L242 6.52x52 TM6 Van der Waals
DS-8500a E261 7.35x34 TM7 polar (hydrogen bond with backbone)
DS-8500a E261 7.35x34 TM7 Van der Waals
DS-8500a R262 7.36x35 TM7 polar (hydrogen bond with backbone)
DS-8500a R262 7.36x35 TM7 polar (charge-assisted hydrogen bond)
DS-8500a W265 7.39x38 TM7 aromatic (face-to-face)
DS-8500a W265 7.39x38 TM7 polar (hydrogen bond)

Ligands

DS-8500a

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Residue Diagrams

T N T A I I L S A L V A L I V G F S F S 1 L N L A V A D T L I G V A I S G L L T D 2 L M V T L V S A A A S S T V F A M R L S 3 A G A C I A G L W L V S Y L I G F L P L 4 F F V F L L M A P F F G V C S L T L V F H 5 S V L I G S F A L S W T P F L I T G I V 6 L P N L L S N G V G L L W L Y R E L V 7
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ICL1 I H K N D ICL1ECL1 S P S ECL1ICL2 P F R Y L K I M ICL2ECL2 P M F Q Q T A Y K G Q C S F F A V ECL2ICL3 A M A G G Y ICL3ECL3 Q E C H L ECL3C-term G V K K V L T S F L L F L S A R N C G P E R P R E S S C H I V T I S S S E F D G C-term M E S S F S F G V I L A V L A S L I I A T N T L V A V A V L L L G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q S G F V A G A C I A G L W L V S Y L I G F L P L G I F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G R S P R T P S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E L Y H V R L Q M A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR119
TM1
1x35 1.35x35 F7
TM2
2x60 2.60x60 L61
TM3
3x32 3.32x32 V85
3x33 3.33x33 T86
3x36 3.36x36 A89
3x37 3.37x37 A90
3x40 3.40x40 V93
3x41 3.41x41 L94
TM4
4x56 4.56x56 I136
ECL2
45x50 45.50x50 C155
45x51 45.51x51 S156
45x52 45.52x52 F157
TM5
5x41 5.40x41 V166
5x44 5.43x44 L169
5x47 5.47x47 G173
5x48 5.48x48 F174
TM6
6x48 6.48x48 W238
6x51 6.51x51 F241
6x52 6.52x52 L242
TM7
7x34 7.35x34 E261
7x35 7.36x35 R262
7x38 7.39x38 W265