(S)-dimetindene
SMILES | CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C |
InChIKey | MVMQESMQSYOVGV-OAHLLOKOSA-N |
Chemical properties
Hydrogen bond acceptors | 2 |
Hydrogen bond donors | 0 |
Rotatable bonds | 5 |
Molecular weight (Da) | 292.2 |
Drug properties
Molecular type | Small molecule |
Physiological/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 6.72 | 6.72 | 6.72 | Guide to Pharmacology |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 7.52 | 7.52 | 7.52 | Guide to Pharmacology |
M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 6.53 | 6.53 | 6.53 | Guide to Pharmacology |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 6.12 | 6.12 | 6.12 | Guide to Pharmacology |
H1 | HRH1 | Human | Histamine | A | pKi | 7.16 | 7.16 | 7.16 | Guide to Pharmacology |
M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 6.12 | 6.12 | 6.12 | ChEMBL |
M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 6.53 | 6.53 | 6.53 | ChEMBL |
H1 | HRH1 | Human | Histamine | A | pKi | 7.16 | 7.16 | 7.16 | ChEMBL |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 6.86 | 6.86 | 6.86 | ChEMBL |
M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 7.52 | 7.52 | 7.52 | ChEMBL |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 6.72 | 6.72 | 6.72 | ChEMBL |
M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 6.86 | 6.86 | 6.86 | Guide to Pharmacology |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 4.4 | 4.4 | 4.4 | ChEMBL |